ArticleTransboundary and emerging diseases2019
Isolation and characterization of equine influenza virus (H3N8) from an equine influenza outbreak in Malaysia in 2015.
Article in Transboundary and emerging diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Genome sequence of equine influenza virus isolated from horses in southeast Kazakhstan in 2020.Microbiology resource announcements · 2023Article
- Equine Influenza Virus and Vaccines.Viruses · 2021Review
- Detection of the epidemic of the H3N8 subtype of the equine influenza virus in large-scale donkey farms.International journal of veterinary science and medicine · 2020Article
- Isolation and characterization of equine influenza virus (H3N8) from an equine influenza outbreak in Malaysia in 2015.Transboundary and emerging diseases · 2019Article
- Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
Equine influenza is a major cause of respiratory infections in horses and can spread rapidly despite the availability of commercial vaccines. In this study, we carried out molecular characterization of Equine Influenza Virus (EIV) isolated from the Malaysian outbreak in 2015 by sequencing of the HA and NA gene segments using Sanger sequencing. The nucleotide and amino acid sequences of HA and NA were compared with representative Florida clade 1 and clade 2 strains using phylogenetic analysis. The Florida clade 1 viruses identified in this outbreak revealed numerous amino acid substitutions in the HA protein as compared to the current OIE vaccine strain recommendations and representative strains of circulating Florida sub-lineage clade 1 and clade 2. Differences in HA included amino acids located within antigenic sites which could lead to reduced immune recognition of the outbreak strain and alter the effectiveness of vaccination against the outbreak strain. Detailed surveillance and genetic information sharing could allow genetic drift of equine influenza viruses to be monitored more effectively on a global basis and aid in refinement of vaccine strain selection for EIV.
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