ArticleMolecular medicine reports2019
The 15d‑PGJ2 hydrogel ameliorates atopic dermatitis through suppression of the immune response.
Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Hydrogels and nanogels: effectiveness in dermal applications.Beilstein journal of nanotechnology · 2025Review
- The contribution of immunohistochemistry to the development of hydrogels for skin repair and regeneration.European journal of histochemistry : EJH · 2023Review
- Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin.International journal of molecular sciences · 2021Article
- Topical Administration of 15-Deoxy-Mediators of inflammation · 2021Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study examined the efficacy of the topical 15d‑PGJ2‑poloxamer 407 hydrogel in an atopic dermatitis (AD) animal model. The 15d‑PGJ2 hydrogel was prepared and characterized. The examined rats possessed AD‑Like cutaneous lesions, which were induced using 2,4‑dinitrochlorobenzene, the rats were then treated with a hydrogel vehicle, 15d‑PGJ2 hydrogel or tacrolimus for 14 days. The rats were sacrificed and blood samples were collected to quantify the IgE levels. Subsequently, skin biopsies were stained with toluidine blue to identify mast cells and immunohistochemistry was performed for ROR‑γt and TNF‑α. Histological analyses demonstrated that 15d‑PGJ2 hydrogel significantly decreased mast cell infiltration (P<0.05) when compared with the AD‑group. Tacrolimus at 0.1% exhibited decreased mast cell infiltration; however, this difference was not statistically significant from the AD‑group. Topical 15d‑PGJ2 hydrogel and Tacrolimus 0.1% significantly reduced the serum levels of IgE (P<0.05) compared with the AD‑group. Immunohistochemistry revealed a significant decrease in ROR‑γt and TNF‑α positive cell expression (P<0.05) in the 15d‑PGJ2 hydrogel group compared with the AD‑group. In summary, topical administration of 15d‑PGJ2 hydrogel had a beneficial effect on AD symptoms, suggesting that this formulation may be a useful strategy for the treatment of AD.
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