ArticleInternational journal of molecular medicine2019
MicroRNA‑199a‑5p suppresses migration and invasion in oral squamous cell carcinoma through inhibiting the EMT‑related transcription factor SOX4.
Article in International journal of molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- RNA-Based Therapeutic Strategies in Multiple Myeloma: From Molecular Targets to Delivery and Clinical Translation.International journal of molecular sciences · 2026Review
- miRNA-199b-5p suppresses of oral squamous cell carcinoma by targeting apical-basolateral polarity via Scribble/Lgl.Molecular therapy. Nucleic acids · 2024Article
- The miR-199a-5p/HIF1α dual-regulatory axis participates in hypoxia-induced aggressive phenotypes of oral squamous cell carcinoma (OSCC) cells.International journal of clinical oncology · 2024Article
- Differential Expression Profile of Salivary oncomiRNAs among Smokeless Tobacco Users.European journal of dentistry · 2023Article
- MiR-199a-5p-Regulated SMARCA4 Promotes Oral Squamous Cell Carcinoma Tumorigenesis.International journal of molecular sciences · 2023Article
- Panoramic view of key cross-talks underpinning the oral squamous cell carcinoma stemness - unearthing the future opportunities.Frontiers in oncology · 2023Review
- Research progress and clinical application prospects of miRNAs in oral cancer.Molecular biology reports · 2022Review
- Using biological information to analyze potential miRNA-mRNA regulatory networks in the plasma of patients with non-small cell lung cancer.BMC cancer · 2022Article
- Long non-coding RNA TTN-AS1/microRNA-199a-3p/runt-related transcription factor 1 gene axis regulates the progression of oral squamous cell carcinoma.Bioengineered · 2021Article
- Identification ofGenes · 2021Article
- hsa_circ_0001018 promotes papillary thyroid cancer by facilitating cell survival, invasion, GMolecular therapy. Nucleic acids · 2021Article
- Article
- Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer.Scientific reports · 2021Observational
- Bioinformatics identification of the candidate microRNAs and construction of a competing endogenous RNA regulatory network in lacrimal gland adenoid cystic carcinoma high-grade transformation.Oncology letters · 2021Article
- MicroRNAs as Modulators of Oral Tumorigenesis-A Focused Review.International journal of molecular sciences · 2021Review
- CCL18-induced LINC00319 promotes proliferation and metastasis in oral squamous cell carcinoma via the miR-199a-5p/FZD4 axis.Cell death & disease · 2020Article
- miR‑144‑3p inhibits tumor cell growth and invasion in oral squamous cell carcinoma through the downregulation of the oncogenic gene, EZH2.International journal of molecular medicine · 2020Article
- Down-regulation of miR-200c associates with poor prognosis of oral squamous cell carcinoma.International journal of clinical oncology · 2020Article
- WISP-1 Promotes Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells Via the miR-153-3p/Snail Axis.Cancers · 2019Article
- LncRNA OIP5-AS1 interacts with miR-363-3p to contribute to hepatocellular carcinoma progression through up-regulation of SOX4.Gene therapy · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRs) are small, non‑coding RNAs that can act as oncogenes or tumor suppressor genes in human cancer. Recent studies have revealed that miR‑199a‑5p is abnormally expressed in various types of human cancer; however, the potential role of miR‑199a‑5p in oral squamous cell carcinoma (OSCC) remains elusive. The present study investigated the role of miR‑199a‑5p in OSCC cells and explored the potential molecular mechanism. Reverse transcription‑quantitative polymerase chain reaction was used to measure miR‑199a‑5p expression in OSCC tissues and adjacent normal oral epithelial tissues. Cell invasion and migration were evaluated using Transwell invasion and wound‑healing assays in OSCC cells post‑transfection with miR‑199a‑5p mimics or negative control mimics. In addition, a luciferase reporter assay was conducted to identify the target gene of miR‑199a‑5p in OSCC cells. The results demonstrated that miR‑199a‑5p expression was significantly downregulated in OSCC tissues and cell lines, and was associated with tumor progression in OSCC. Furthermore, overexpression of miR‑199a‑5p inhibited cell invasion and migration, and blocked the epithelial‑mesenchymal transition (EMT) cascade. Notably, the results revealed that the EMT‑related transcription factor SRY‑box 4 (SOX4) was a direct target gene of miR‑199a‑5p, as determined by the direct binding of miR‑199a‑5p with the 3'‑untranslated region of SOX4. In addition, knockdown of SOX4 by small interfering RNA‑SOX4 suppressed proliferation, migration and invasion of OSCC cells. Conversely, overexpression of SOX4 rescued the suppressive effects of miR‑199a‑5p on cell migration and invasion. Collectively, these data indicated that miR‑199a‑5p may inhibit the migration and invasion of OSCC cells via targeting the EMT‑related transcription factor SOX4, thus suggesting that miR‑199a‑5p may serve as a prognostic biomarker and therapeutic target in the treatment of OSCC.
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