ArticleThe Journal of clinical endocrinology and metabolism2019
High-Normal Adolescent Fasting Plasma Glucose Is Associated With Poorer Midlife Brain Health: Bogalusa Heart Study.
Article in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study.NeuroImage · 2025Article
- Associations between physical activity, brain health, cognitive function, and circulating GPLD1 in healthy older (65-85 years) individuals.GeroScience · 2025Observational
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study.NeuroImage · 2025Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke.Frontiers in aging neuroscience · 2024Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Race and sex differences in the association between lifespan glycemic status and midlife cognitive function: the Bogalusa heart study.Frontiers in public health · 2023Article
- Brain effective connectivity and functional connectivity as markers of lifespan vascular exposures in middle-aged adults: The Bogalusa Heart Study.Frontiers in aging neuroscience · 2023Article
- Au et al. Respond to "Body Mass Index and Risk of Dementia".American journal of epidemiology · 2021Article
- White matter hyperintensity volume in pre-diabetes, diabetes and normoglycemia.BMJ open diabetes research & care · 2021Article
- One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
contextIt is unclear how adolescent glycemic status relates to brain health in adulthood.
objectiveTo assess the association between adolescent fasting plasma glucose (FPG) and MRI-based brain measures in midlife.
designBetween 1973 and 1992, the Bogalusa Heart Study (BHS) collected FPG from children, 3 to 18 years old, and followed up between 1992 and 2018. Cognitive tests and brain MRI were collected in 2013 to 2016 and 2018.
settingObservational longitudinal cohort study.
participantsOf 1298 contacted BHS participants, 74 completed screening, and 50 completed MRI.
main outcome measuresMean FPG per participant at ages <20, 20 to 40, and over 40 years old; brain white matter hyperintensity (WMH) volume, gray matter volume, and functional MRI (fMRI) activation to a Stroop task; tests of logical and working memory, executive function, and semantic fluency.
resultsAt MRI, participants were middle aged (51.3 ± 4.4 years) and predominantly female (74%) and white (74%). Mean FPG was impaired for zero, two, and nine participants in pre-20, 20 to 40, and over-40 periods. The pre-20 mean FPG above the pre-20 median value (i.e., above 83.5 mg/dL) was associated with greater WMH volume [mean difference: 0.029% of total cranial volume, CI: (0.0059, 0.052), P = 0.015] and less fMRI activation [-1.41 units (-2.78, -0.05), P = 0.043] on midlife MRI compared with below-median mean FPG. In controlling for over-40 mean FPG status did not substantially modify the associations. Cognitive scores did not differ by pre-20 mean FPG.
conclusionsHigh-normal adolescent FPG may be associated with preclinical brain changes in midlife.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.