ReviewPlant & cell physiology2019
Iron Biofortification of Staple Crops: Lessons and Challenges in Plant Genetics.
Review in Plant & cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 176 citations in OpenAlex.
- Accelerating iron biofortification in millets: progress, challenges, and future prospects.Planta · 2026Review
- Establishment of a Non-transgenic Iron-Biofortified Rice Line Using a Novel HRZ1 Mutation.Rice (New York, N.Y.) · 2026Article
- OsFPN1 functions as an essential metal transporter for Fe homeostasis and Co/Ni tolerance in rice.Plant molecular biology · 2026Article
- Article
- Molecular Basis for Vacuolar Iron Transport by OsVIT2, a Target for Iron Biofortification in Rice.Proteins · 2025Article
- Deficiency and Development: A Bibliometric Analysis of the Effects of Iron Deficiency on Human Development.Cureus · 2025Review
- Engineering of nicotianamine synthesis enhances cadmium mobility in plants and results in higher seed cadmium concentrations.The Plant journal : for cell and molecular biology · 2025Article
- Shortcutting Photorespiration Protects Potato Photosynthesis and Tuber Yield Against Heatwave Stress.Global change biology · 2024Article
- Impact of iron sulfate (FeSOScientific reports · 2024Article
- Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes.British journal of haematology · 2024Review
- Uncovering the genomic regions underlying grain iron and zinc content using genome-wide association mapping in finger millet.3 Biotech · 2024Article
- Genetic basis of the historical iron-accumulating dgl and brz mutants in pea.The Plant journal : for cell and molecular biology · 2024Article
- Article
- Plant Iron Research in African Countries: Current "Hot Spots", Approaches, and Potentialities.Plants (Basel, Switzerland) · 2023Review
- Genetically Modified Rice Is Associated with Hunger, Health, and Climate Resilience.Foods (Basel, Switzerland) · 2023Review
- Nicotianamine: A Key Player in Metal Homeostasis and Hyperaccumulation in Plants.International journal of molecular sciences · 2023Review
- Deciphering host-pathogen interaction during Streptomyces spp. infestation of potato.Archives of microbiology · 2023Review
- The potential of bamboo seeds for natural biofortification of dietary zinc and iron.NPJ science of food · 2023Article
- Genetically modified foods: bibliometric analysis on consumer perception and preference.GM crops & food · 2022Article
- Simultaneous Enhancement of iron Deficiency Tolerance and Iron Accumulation in Rice by Combining the Knockdown of OsHRZ Ubiquitin Ligases with the Introduction of Engineered Ferric-chelate Reductase.Rice (New York, N.Y.) · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants are the ultimate source of iron in our diet, either directly as staple crops and vegetables or indirectly via animal fodder. Increasing the iron concentration of edible parts of plants, known as biofortification, is seen as a sustainable approach to alleviate iron deficiency which is a major global health issue. Advances in sequencing and gene technology are accelerating both forward and reverse genetic approaches. In this review, we summarize recent progress in iron biofortification using conventional plant breeding or transgenics. Interestingly, some of the gene targets already used for transgenic approaches are also identified as genetic factors for high iron in genome-wide association studies. Several quantitative trait loci and transgenes increase both iron and zinc, due to overlap in transporters and chelators for these two mineral micronutrients. Research efforts are predominantly aimed at increasing the total concentration of iron but enhancing its bioavailability is also addressed. In particular, increased biosynthesis of the metal chelator nicotianamine increases iron and zinc levels and improves bioavailability. The achievements to date are very promising in being able to provide sufficient iron in diets with less reliance on meat to feed a growing world population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.