ArticleCerebral cortex (New York, N.Y. : 1991)2020
Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- Defining exceptional cognition in older adults: A systematic review of cognitive super-ageing.International journal of geriatric psychiatry · 2023Pooled it
- Understanding brain resilience in superagers: a systematic review.Neuroradiology · 2021Pooled it
- Processing speed and attention training modifies autonomic flexibility: A mechanistic intervention study.NeuroImage · 2020Trial
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- A harmonized framework for studying exceptional cognitive aging in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Amyloid burden, brain metabolism, and gray matter volume in SuperAgers.Arquivos de neuro-psiquiatria · 2026Article
- Structural and functional alterations of posterior cingulate cortex subregions in successful cognitive aging.Frontiers in aging neuroscience · 2026Article
- Abnormal functional network connectivity mediates the relationship between depressive symptoms and cognitive decline in late-onset depression.Psychological medicine · 2025Article
- Altered dynamic regional homogeneity and neurovascular coupling in multi-frequency bands in patients with cerebral small vascular disease.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Functional Connectome of Superagers Reveals Early Markers of Resilience and Vulnerability to Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
- Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions.Neurobiology of aging · 2025Article
- Identification of key brain networks and functional connectivities of successful aging: A surface-based resting-state functional magnetic resonance study.World journal of psychiatry · 2025Article
- Sex Matters: Association with Superager Classification and Risk Factors.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Cognitive and Salience Network Connectivity Changes following a Single Season of Repetitive Head Impact Exposure in High School Football.AJNR. American journal of neuroradiology · 2024Article
- Mnemonic But Not Contextual Feedback Signals Defy Dedifferentiation in the Aging Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Transcranial direct current stimulation and neuronal functional connectivity in MCI: role of individual factors associated to AD.Frontiers in psychiatry · 2024Article
- Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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5 authors.
Funding
Abstract
"Superagers" are older adults who, despite their advanced age, maintain youthful memory. Previous morphometry studies revealed multiple default mode network (DMN) and salience network (SN) regions whose cortical thickness is greater in superagers and correlates with memory performance. In this study, we examined the intrinsic functional connectivity within DMN and SN in 41 young (24.5 ± 3.6 years old) and 40 older adults (66.9 ± 5.5 years old). Superaging was defined as youthful performance on a memory recall task, the California Verbal Learning Test (CVLT). Participants underwent a resting-state functional magnetic resonance imaging (fMRI) scan and performed a separate visual-verbal recognition memory task. As predicted, within both DMN and SN, superagers had stronger connectivity compared with typical older adults and similar connectivity compared with young adults. Superagers also performed similarly to young adults and better than typical older adults on the recognition task, demonstrating youthful episodic memory that generalized across memory tasks. Stronger connectivity within each network independently predicted better performance on both the CVLT and recognition task in older adults. Variation in intrinsic connectivity explained unique variance in memory performance, above and beyond youthful neuroanatomy. These results extend our understanding of the neural basis of superaging as a model of successful aging.
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