Evidence map›Paper›PMID 31058883›Full record

ArticleJournal of visualized experiments : JoVE2019

Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain.

Faddi G Saleh Velez, Camila B Pinto, Emma S Bailin, Marionna Münger, Andrew Ellison, Beatriz T Costa, David Crandell, Nadia Bolognini, Lotfi B Merabet, Felipe Fregni

Registry-linked trialOpen access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04285138 (Effects of Phantom Exercises on Pain, Mobility and Quality of Life Among Lower Limb Amputees), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04285138 nacompletednot on this mapstarted 2020, after this paper: background citation

Effects of Phantom Exercises on Pain, Mobility and Quality of Life Among Lower Limb Amputees

TypeinterventionalSponsorRiphah International UniversityRan2020 to 2020Enrolled24ConditionsLower Limb AmputationArmsphantom limb exercise, conventional treatment
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Faddi G Saleh VelezLaboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital; University of Chicago Medical Center, Department of Neurology, University of Chicago.
Camila B PintoLaboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital; Department of Neuroscience and Behavior, Psychology Institute, University of Sao Paulo.
Emma S BailinThe Laboratory for Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School.
Marionna MüngerLaboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital.
Andrew EllisonCenter for Biomedical Imaging, Department of Anatomy and Neurobiology, Boston University School of Medicine.
Beatriz T CostaLaboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital.
David CrandellSpaulding Rehabilitation Hospital, Harvard Medical School.
Nadia BologniniDepartment of Psychology & Milan Center for Neuroscience, University of Milano-Bicocca; Neuropsychological Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Auxologico Italiano.
Lotfi B MerabetThe Laboratory for Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School.
Felipe FregniLaboratory of Neuromodulation & Center for Clinical Research Learning, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital; fregni.felipe@mgh.harvard.edu.
Harvard University · USBoston University · USUniversidade de São Paulo · BRUniversity of Chicago Medical Center · USUniversity of Milano-Bicocca · IT

Funding

Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain with Machine Learning to Predict Treatment ResponseR01HD082302 · NICHD · SPAULDING REHABILITATION HOSPITAL · PI Felipe Fregni · 2015 to 2026
$4.7M
NICHD NIH HHS R01 HD082302
6 · The paper itself

Abstract

Mirror therapy (MT) has been proposed as an effective rehabilitative strategy to alleviate pain symptoms in amputees with phantom limb pain (PLP). However, establishing the neural correlates associated with MT therapy have been challenging given that it is difficult to administer the therapy effectively within a magnetic resonance imaging (MRI) scanner environment. To characterize the functional organization of cortical regions associated with this rehabilitative strategy, we have developed a combined behavioral and functional neuroimaging protocol that can be applied in participants with a leg amputation. This novel approach allows participants to undergo MT within the MRI scanner environment by viewing real-time video images captured by a camera. The images are viewed by the participant through a system of mirrors and a monitor that the participant views while lying on the scanner bed. In this manner, functional changes in cortical areas of interest (e.g., sensorimotor cortex) can be characterized in response to the direct application of MT.

Indexed as

Magnetic Resonance ImagingAmputeesHumansMaleMiddle AgedPhantom LimbVideo Recording

Identifiers

PMID31058883
PMCPMC6510542
OpenAlexW2937970905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.