Evidence map›Paper›PMID 31058802›Full record

ArticlePharmaceutics2019

Nanomedicines for the Delivery of Biologics.

John Wahlich, Arpan Desai, Francesca Greco, Kathryn Hill, Arwyn T Jones, Randall J Mrsny, Gianfranco Pasut, Yvonne Perrie, F Philipp Seib, Leonard W Seymour and 1 more

Open access · goldAbstract readConference Proceedings
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 47 citations in OpenAlex.

  1. High-velocity delivery of biologics via the gastrointestinal tract by self-pressurized oral capsules.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  2. Silk Bioconjugates: From Chemistry and Concept to Application.ACS biomaterials science & engineering · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

John WahlichThe Academy of Pharmaceutical Sciences, 4 Heydon Road, Great Chishill, Royston SG8 8SR, UK. John.Wahlich@btinternet.com.ORCID 0000-0002-2590-4634
Arpan DesaiAdvanced Drug Delivery, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Granta Park, Cambridge CB21 6GH, UK. Arpan.Desai@astrazeneca.com.
Francesca GrecoReading School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, UK. f.greco@reading.ac.uk.
Kathryn HillGlobal Product Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield SK10 2NA, UK. Kathryn.Hill@astrazeneca.com.
Arwyn T JonesCardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK. JonesAT@cardiff.ac.uk.ORCID 0000-0003-2781-8905
Randall J MrsnyDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. r.j.mrsny@bath.ac.uk.ORCID 0000-0001-8505-8516
Gianfranco PasutPharmaceutical and Pharmacological Sciences Department, University of Padova, F. Marzolo 5, 35131 Padova, Italy. gianfranco.pasut@unipd.it.ORCID 0000-0002-8754-0899
Yvonne PerrieStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. yvonne.perrie@strath.ac.uk.
F Philipp SeibStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. philipp.seib@strath.ac.uk.
Leonard W SeymourDepartment of Oncology, Old Road Campus Research Building, Oxford OX3 7DQ, UK. len.seymour@oncology.ox.ac.uk.
Ijeoma F UchegbuUCL School of Pharmacy, London WC1N 1AX, UK. ijeoma.f.uchegbu@pharmacy.ac.uk.
AstraZeneca (United Kingdom) · GBUniversity of Strathclyde · GBBritish Academy · GBCardiff University · GBThe London College · GBUniversity of Bath · GBUniversity of Padua · ITUniversity of Reading · GB

Funding

Cancer Research UK 29106
6 · The paper itself

Abstract

A special symposium of the Academy of Pharmaceutical Sciences Nanomedicines Focus Group reviewed the current status of the use of nanomedicines for the delivery of biologics drugs. This meeting was particularly timely with the recent approval of the first siRNA-containing product Onpattro™ (patisiran), which is formulated as a lipid nanoparticle for intravenous infusion, and the increasing interest in the use of nanomedicines for the oral delivery of biologics. The challenges in delivering such molecules were discussed with specific emphasis on the delivery both across and into cells. The latest developments in Molecular Envelope Technology

Indexed as

DNAdrug deliveryendocytosislipid nanoparticlesliposomesmRNAnanomedicinesproteinssiRNAviral vectors

Identifiers

PMID31058802
PMCPMC6572454
OpenAlexW2943784202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.