ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2019
Temporal Bone Histopathology of First-Generation Cochlear Implant Electrode Translocation.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Factors Affecting Audiometric and Speech Perception Outcomes in Hybrid Cochlear Implant Recipients.The Laryngoscope · 2026Article
- Cochlear Implant Insertion Trauma Is Associated With Spiral Ganglion Neuron "Dead Zones" in the Human.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- Understanding the Mechanisms Driving Fibrosis Following Cochlear Implantation-Lessons from Other Tissues.Cells · 2025Review
- Interaural correlation of acoustic hearing preservation following sequential cochlear implantation.Frontiers in neurology · 2025Article
- Innovative computed tomography based mapping of the surgical posterior tympanotomy: An exploratory study.Heliyon · 2024Article
- Impact of Insertion Speed, Depth, and Robotic Assistance on Cochlear Implant Insertion Forces and Intracochlear Pressure: A Scoping Review.Sensors (Basel, Switzerland) · 2024Article
- Contribution of macrophages to neural survival and intracochlear tissue remodeling responses following cochlear implantation.Journal of neuroinflammation · 2023Article
- Archival Human Temporal Bone: Anatomical and Histopathological Studies of Cochlear Implantation.Journal of personalized medicine · 2023Review
- Anatomical Variations of the Human Cochlea Using an Image Analysis Tool.Journal of clinical medicine · 2023Article
- The effect of the surgical approach and cochlear implant electrode on the structural integrity of the cochlea in human temporal bones.Scientific reports · 2022Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Histopathologic Analysis of Temporal Bones With Otosclerosis Following Cochlear Implantation.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2021Article
- Using the electrically-evoked compound action potential (ECAP) interphase gap effect to select electrode stimulation sites in cochlear implant users.Hearing research · 2021Article
- Meta-Analysis-Correlation between Spiral Ganglion Cell Counts and Speech Perception with a Cochlear Implant.Audiology research · 2021Review
- Human Temporal Bone Study of Vestibular Histopathology in Cochlear Implant Patients With Cochlear Hydrops.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2020Article
- Morphometric linear and angular measurements of the human cochlea in implant patients using 3-dimensional reconstruction.Hearing research · 2020Article
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Abstract
objectiveTo evaluate the histopathology of human temporal bones (HTBs) with cochlear implants (CI).
backgroundUnderstanding CI translocation injuries is critical for improving outcomes. MATERIAL AND
methodsThirteen HTBs from 12 CI patients were studied. Six HTBs exhibited translocation with localized injury (Group 1) and seven HTBs exhibited translocation with significant lateral wall injury (Group 2). There were no significant differences between Group 1 and Group 2 for age at death, age at implantation, and years with CI.
resultsFour out of six of Group 1 had round window approach, while all seven of Group 2 had cochleostomy approach. Translocation injuries tended to occur near 180 degrees of angular insertion with a mean of 186.36 ± 51.62 degrees. Average CI insertion length for Group 2 was 21.86 ± 2.55 mm, significantly longer than Group 1 at 18.50 ± 3.33 mm (p = 0.031). Group 1 had an average of 17300 ± 9415 spiral ganglia neurons (SGNs) while Group 2 had significantly fewer SGNs 6714 ± 4269 (p = 0.015). Group 1 average auditory performance of 66.55 ± 27.20% was higher than that of Group 2 of 39.86 ± 15.36%. Group 2 had a high degree of osteoneogenesis and infiltration of cells generally localized to areas of translocation injury and cochleostomy.
conclusionTranslocation injuries tend to occur at an insertion angle of 180 degrees, at 9 to 10 mm. Lateral wall injury and damage to the organ of Corti incites fibrosis, osteoneogenesis, and infiltration, lower SGN count and poorer auditory performance. Longer electrodes were more prone to translocation and higher chance of significant intracochlear injury.
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