ArticleAlzheimer disease and associated disorders
Stressors in Midlife and Risk of Dementia: The Role of Race and Education.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Beyond "normative" loss: social context, loss integration, and adaptation to parental bereavement in midlife.BMC psychology · 2026Article
- The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of Ageing.Journal of Alzheimer's disease : JAD · 2026Article
- Psychosocial hierarchies of modifiable risk for Alzheimer's disease: A networks analysis.PloS one · 2026Article
- Is the Health of Older Americans With a GED Equivalent to Their Peers With a High School Diploma?International journal of aging & human development · 2024Article
- Experimental laboratory models as tools for understanding modifiable dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Race, community disadvantage, and cognitive decline: Findings from KHANDLE and STAR.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Empirically derived psychosocial-behavioral phenotypes in Black/African American and Hispanic/Latino older adults enrolled in HABS-HD: Associations with AD biomarkers and cognitive outcomes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.Neurology. Genetics · 2021Article
- Design and overview of the Origins of Alzheimer's Disease Across the Life course (ORACLE) study.European journal of epidemiology · 2021Review
- A Multimodal Risk Network Predicts Executive Function Trajectories in Non-demented Aging.Frontiers in aging neuroscience · 2021Article
- Associations between education and dementia in the Caribbean and the United States: An international comparison.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Women's Work-Family Histories and Cognitive Performance in Later Life.American journal of epidemiology · 2020Article
- Alzheimer's Disease and Alzheimer's Disease-Related Dementias in Older African American and White Veterans.Journal of Alzheimer's disease : JAD · 2020Article
- Polymorphisms of Proinflammatory Cytokines in Relation to APOE Epsilon 4 and Risk of Alzheimer's Disease in the Lithuanian Population.Medicina (Kaunas, Lithuania) · 2019Article
- Expanding the scope of health disparities research in Alzheimer's disease and related dementias: Recommendations from the "Leveraging Existing Data and Analytic Methods for Health Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias" Workshop Series.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer's Disease and Related Dementia.American journal of Alzheimer's disease and other dementiasArticle
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Authors and funding
6 authors.
Funding
Abstract
backgroundPosttraumatic stress disorder is associated with increased dementia risk but less is known about stress because of everyday problems in diverse populations.
methodsA total of 9605 health care plan members who provided information regarding midlife stressors in 1972 to 1973 (ages, 40 to 55 y) were followed for dementia diagnosis between 1996 and 2017. Cox proportional hazard models evaluated associations between midlife stressors and dementia adjusting for demographics and lifecourse health indicators.
resultsReporting at least 1 midlife stressor was associated with 17% greater dementia risk [hazard ratio (HR), 1.17; 95% confidence interval (CI),1.07-1.27] versus 0 midlife stressors and 26% increased risk among those with less than equal to high school education (HR, 1.26; 95% CI,1.09-1.44) adjusting for demographics. Compared with whites without stressors, whites with ≥1 stressor had 13% greater dementia risk (HR, 1.13; 95% CI, 1.02-1.24), blacks without stressors 19% greater risk (HR, 1.19; 95% CI,1.08-1.32), and blacks with ≥1 stressors 47% greater risk (HR, 1.47; 95% CI,1.27-1.69) in fully adjusted models. Resource problems were associated with 20% greater risk (HR, 1.20; 95% CI, 1.01-1.42) than interpersonal problems.
conclusionReporting ≥1 serious midlife stressor was associated with elevated dementia risk, especially stressors related to resources problems and for those with less than equal to high school education. Everyday stressors can impact brain health over the long term and may contribute to racial inequities in dementia rates, though education can be a mitigating factor.
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