Evidence map›Paper›PMID 31058677›Full record

ReviewCurrent opinion in allergy and clinical immunology2019

Eosinophilic esophagitis during sublingual and oral allergen immunotherapy.

Joseph Cafone, Peter Capucilli, David A Hill, Jonathan M Spergel

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 64 citations in OpenAlex.

  1. Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. [Systemic treatment of allergies].Dermatologie (Heidelberg, Germany) · 2025
    Review
  6. Eosinophilic esophagitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
    Review
  7. Allergen immunotherapy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. The Relationship Between Eosinophilic Esophagitis and Immunotherapy.Immunology and allergy clinics of North America · 2024
    Review
  13. Practical issues of oral immunotherapy for egg or milk allergy.Clinical and experimental pediatrics · 2024
    Article
  14. Article
  15. The KAAACI Guidelines for Sublingual Immunotherapy.Allergy, asthma & immunology research · 2024
    Review
  16. Article
  17. A case of food and aeroallergen sublingual immunotherapy inducing eosinophilic esophagitis.The journal of allergy and clinical immunology. Global · 2023
    Article
  18. Review
  19. Review
  20. Breaking down the complex pathophysiology of eosinophilic esophagitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Joseph CafoneDivision of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia.
Peter CapucilliDivision of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia.
David A HillDivision of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia.
Jonathan M SpergelDivision of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Maurizio Macaluso · 2019 to 2026
$51.2M
TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI GLENN T FURUTA · 2014 to 2026
$18.5M
The role of unique adipose tissue macrophage populations in obesityK08DK116668 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI HILL, DAVID ANDREW · 2018 to 2022
$770k
NCATS NIH HHS U2C TR002818NIAID NIH HHS U54 AI117804NIDDK NIH HHS K08 DK116668
6 · The paper itself

Abstract

purpose of reviewThe aim of this review is to discuss the current evidence regarding the development of eosinophilic esophagitis (EoE) in individuals undergoing oral and sublingual immunotherapy (SLIT) for both food and environmental allergens. Cumulative incidence of EoE in patients on allergen immunotherapy for peanut, milk, and egg is estimated. RECENT

findingsDe novo development of EoE in patients undergoing oral and SLIT has been demonstrated on the scale of case reports and prospective randomized trials. However, few individuals with EoE-like symptoms during immunotherapy undergo endoscopy, and the long-term outcomes of immunotherapy-associated EoE are unknown. SUMMARY: Evidence exists to suggest that allergen immunotherapy could place individuals at risk for the development of EoE, the true incidence of which may vary depending on antigen exposure and methods used to define the condition.

Indexed as

Administration, OralAdministration, SublingualAnimalsDesensitization, ImmunologicDrug-Related Side Effects and Adverse ReactionsEosinophilic EsophagitisHumansHypersensitivityRandomized Controlled Trials as TopicRisk

Identifiers

PMID31058677
PMCPMC6639051
OpenAlexW2944271183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.