ArticleThe journal of international advanced otology2019
The Polymorphic Analysis of the Human Potassium Channel KCNE Gene Family in Meniere's Disease-A Preliminary Study.
Article in The journal of international advanced otology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- A Systematic Review on the Role of the Stria Vascularis in Menière's Disease Pathogenesis.Journal of the Association for Research in Otolaryngology : JARO · 2025Pooled it
- Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis.Frontiers in neurology · 2021Pooled it
- Research progress on the mechanisms and animal models of Ménière's disease.Genes & diseases · 2026Review
- KCNE gene family: From basic functions to diseases.Genes & diseases · 2026Review
- The Impact of Genetic Factors in Ménière's Disease.International journal of molecular sciences · 2026Review
- Genetic advances in Meniere Disease.Molecular biology reports · 2023Review
- The role of the stria vascularis in neglected otologic disease.Hearing research · 2023Review
- Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis.Frontiers in molecular neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the correlation between KCNE gene family and Meniere's disease (MD) in the Chinese population. MATERIALS AND
methodsThis study analyzed the single-nucleotide polymorphism (SNP) of KCNE1 and KCNE3 genes between the MD group and the control group and between the familial Meniere's disease (FMD) group and the sporadic Meniere's disease (SMD) group.
resultsA total of 653 C/T SNPs of KCNE1 had a statistical difference between the FMD and SMD groups (p=0.0082<0.05); 492 A/C SNPs of KCNE3 were statistically different between the FMD group and the control group (genotype p=0.037<0.05 and allele p=0.006<0.05).
conclusionSNPs of KCNE1 and KCNE3 gene mutations were, respectively, different between the SMD and FMD groups. KCNE3 gene polymorphism was key to FMD disease, whereas KCNE1 was more important to the onset of SMD.
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Registered trials
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