Evidence map›Paper›PMID 31058515›Full record

ArticleOrganic letters2019

Three-Component Protein Modification Using Mercaptobenzaldehyde Derivatives.

Yuanwei Dai, Jiaping Weng, Justin George, Huan Chen, Qishan Lin, Jun Wang, Maksim Royzen, Qiang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuanwei DaiDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.
Jiaping WengDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.
Justin GeorgeDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.
Huan ChenDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.ORCID 0000-0003-1682-8809
Qishan LinDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.ORCID 0000-0002-1756-1432
Jun WangDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.ORCID 0000-0002-8781-8248
Maksim RoyzenDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.ORCID 0000-0002-2930-2171
Qiang ZhangDepartment of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.ORCID 0000-0003-2787-1781

Funding

Development of Single-Cell Multiplex in Situ Tagging Microtechnology for Comprehensive Profiling of Functionally Diverse Subpopulations and Their Signaling PathwaysR01GM128984 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI WANG, JUN · 2018 to 2021
$1.3M
NIGMS NIH HHS R01 GM128984
6 · The paper itself

Abstract

A chemoselective primary amine modification strategy that enables the three-component, one-pot bioconjugation is described. The specifically designed, mercaptobenzaldehyde-based bifunctional linker achieves highly selective and robust amine labeling under biocompatible conditions. This linker demonstrates wide functional group tolerance and is simple to prepare, which allowed facile payload incorporation. Finally, our studies have shown that the introduction of linker does not impair the function of modified protein such as insulin.

Indexed as

AminesBenzaldehydesMolecular StructureProtein Processing, Post-TranslationalSulfhydryl CompoundsAminesBenzaldehydesSulfhydryl Compounds

Identifiers

PMID31058515
PMCPMC6767916

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.