ArticleHippocampus2019
NMDA receptor activity bidirectionally controls active decay of long-term spatial memory in the dorsal hippocampus.
Article in Hippocampus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Rumex acetosa L. enhance learning and cognitive function by modulating NMDA receptor and BDNF pathways in vitro and in vivo.Metabolic brain disease · 2025Article
- Memory persistence: from fundamental mechanisms to translational opportunities.Translational psychiatry · 2024Review
- Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory.Molecular psychiatry · 2023Review
- Forgetting as a form of adaptive engram cell plasticity.Nature reviews. Neuroscience · 2022Review
- The Black Box effect: sensory stimulation after learning interferes with the retention of long-term object location memory in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- Distributed interactive brain circuits for object-in-place memory: A place for time?Brain and neuroscience advancesReview
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The time-dependent forgetting of long-term spatial memories involves activation of NMDA receptors (NMDARs) in the hippocampus. Here, we tested whether NMDARs regulate memory persistence bidirectionally, decreasing or increasing the rate of forgetting. We found that blocking NMDAR activation with AP5 or the GluN2B-selective antagonist Ro25-6981 in the dorsal hippocampus (dHPC) prevented the natural forgetting of long-term memory for the locations of objects in an open field arena. In contrast, while enhancing NMDAR function with the partial agonist D-Cycloserine did not affect the speed of forgetting for these types of memories, infusing the NMDAR co-agonist D-Serine significantly shortened their persistence. These results suggest that NMDAR activity can modulate the speed of constitutive long-term memory decay in the dHPC and that regulating NMDAR expression and D-Serine availability could provide a mechanism to control the duration of long-term memory.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.