Evidence map›Paper›PMID 31058383›Full record

ReviewGlia2020

A roadmap to integrate astrocytes into Systems Neuroscience.

Ksenia V Kastanenka, Rubén Moreno-Bote, Maurizio De Pittà, Gertrudis Perea, Abel Eraso-Pichot, Roser Masgrau, Kira E Poskanzer, Elena Galea

Open access · bronzeAbstract readReview
In one paragraph

Review in Glia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Modeling traveling calcium waves in cellular structures.Journal of computational neuroscience · 2025
    Article
  11. Neuron-astrocyte associative memory.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Ksenia V KastanenkaDepartment of Neurology, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Rubén Moreno-BoteCenter for Brain and Cognition and Department of Information and Communications Technologies, Universitat Pompeu Fabra, Barcelona, Spain.
Maurizio De PittàBCAM Basque Center for Applied Mathematics, Bilbao, Spain.
Gertrudis PereaInstituto Cajal, CSIC, Madrid, Spain.ORCID 0000-0001-5924-9175
Abel Eraso-PichotInstitut de Neurociències i Departament de Bioquímica, Universitat Autònoma de Barcelona, Barcelona, Spain.
Roser MasgrauInstitut de Neurociències i Departament de Bioquímica, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-6722-5939
Kira E PoskanzerDepartment of Biochemistry & Biophysics, Neuroscience Graduate Program, and Kavli Institute for Fundamental Neuroscience, University of California-San Francisco, San Francisco, California.
Elena GaleaICREA, Barcelona, Spain.ORCID 0000-0003-4537-9897
Institució Catalana de Recerca i Estudis Avançats · ESUniversitat Autònoma de Barcelona · ESBasque Center for Applied Mathematics · ESHarvard University · USInstituto Cajal · ESUniversity of California, San Francisco · US

Funding

The role of astrocytes in Alzheimer's disease pathogenesisR01AG054598 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Brian J Bacskai · 2017 to 2026
$4.4M
Non-invasive optical imaging of neuropathology in vivoR01AG026240 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BACSKAI, BRIAN J · 2006 to 2010
$4.1M
A Functional Taxonomy of Cortical AstrocytesR01NS099254 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Evan Harriman Feinberg · 2017 to 2026
$4.1M
Slow-wave activity as a modifier of the progression of neurodegeneration in Alzheimer's diseaseRF1AG061774 · NIA · HARVARD MEDICAL SCHOOL · PI BACSKAI, BRIAN J, GERASHCHENKO, DMITRY · 2019 to 2021
$3.7M
NIA NIH HHS R01 AG026240NIA NIH HHS R01 AG054598NIA NIH HHS RF1 AG061774NINDS NIH HHS R01 NS099254
6 · The paper itself

Abstract

Systems neuroscience is still mainly a neuronal field, despite the plethora of evidence supporting the fact that astrocytes modulate local neural circuits, networks, and complex behaviors. In this article, we sought to identify which types of studies are necessary to establish whether astrocytes, beyond their well-documented homeostatic and metabolic functions, perform computations implementing mathematical algorithms that sub-serve coding and higher-brain functions. First, we reviewed Systems-like studies that include astrocytes in order to identify computational operations that these cells may perform, using Ca

Indexed as

AnimalsAstrocytesBrainBrain ChemistryHumansNeuronsNeurosciencesOptogeneticsSystems Biologyastrocytesdecodingdimensionality reductionenergy-efficient codingpredictive coding

Identifiers

PMID31058383
PMCPMC6832773
OpenAlexW2944697917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.