Evidence map›Paper›PMID 31058201›Full record

ArticleJournal of applied bioinformatics & computational biology2018

Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of B

Yuan Zhou, Lintao Chen, Xi Zhou, Yechun Pei, Shuangshuang Wei, Anum Mehmood, Yang K Xiang, Dayong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied bioinformatics & computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Yuan Zhou *Laboratory of Biotechnology and Molecular Pharmacology, Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan 570208, China.
Lintao Chen *Laboratory of Biotechnology and Molecular Pharmacology, Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan 570208, China.
Xi ZhouLaboratory of Biotechnology and Molecular Pharmacology, Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan 570208, China.
Yechun PeiLaboratory of Biotechnology and Molecular Pharmacology, Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan 570208, China.
Shuangshuang WeiLaboratory of Biotechnology and Molecular Pharmacology, Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan 570208, China.
Anum MehmoodLaboratory of Biotechnology and Molecular Pharmacology, Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan 570208, China.
Yang K XiangDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Dayong WangLaboratory of Biotechnology and Molecular Pharmacology, Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan 570208, China.
Hainan University · CN

Funding

Spatiotemporal regulation of beta adrenoceptor signaling in cardiacmyocytesR01HL082846 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI XIANG, YANG K · 2006 to 2014
$3.0M
Novel mechanism on subpopulation-dependent biased GPCR signaling in neuronsR01GM129376 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL082846NIGMS NIH HHS R01 GM129376
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a lifelong progressive neurodegenerativa disease related with accumulation of amyloid β peptide (Aβ) produced by processing of amyloid precursor protein (APP) in the brain. In spite of several-decades effort on AD, there is still no medicine used to intervene with its pathological processes. Our previous studies made in transgenic animal models harboring familial AD genes of mutant presenilin 1 and amyloid precursor protein (APP) showed that β

Indexed as

Alzheimer’s diseaseDifferential expressionGenomeLysosomeProtein processing and presentationβ2 adrenergic receptor

Identifiers

PMID31058201
PMCPMC6497178
OpenAlexW2901023078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.