Evidence map›Paper›PMID 31058081›Full record

ArticleFrontiers in oncology2019

Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives.

Minghui Wan, Lei Zhang, Yiming Chen, Qiang Li, Wenli Fan, Qingxia Xue, Fang Yan, Weiguo Song

Abstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps.Journal of enzyme inhibition and medicinal chemistry · 2021
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minghui WanSchool of Pharmacy, Weifang Medical University, Weifang, China.
Lei ZhangSchool of Pharmacy, Weifang Medical University, Weifang, China.
Yiming ChenSchool of Pharmacy, Weifang Medical University, Weifang, China.
Qiang LiSchool of Pharmacy, Weifang Medical University, Weifang, China.
Wenli FanSchool of Pharmacy, Weifang Medical University, Weifang, China.
Qingxia XueSchool of Pharmacy, Weifang Medical University, Weifang, China.
Fang YanSchool of Pharmacy, Weifang Medical University, Weifang, China.
Weiguo SongSchool of Pharmacy, Weifang Medical University, Weifang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on the structure of sanguinarine, fourteen phenanthridine derivatives were designed and synthesized in the current study. The cytotoxic activities of synthesized compounds were evaluated against five human cancer cell lines (MCF-7, PC3, Hela, A549, and HepG2 cell lines) via MTT assay. Among all the compounds tested, molecule

Indexed as

anticancerapoptosiscell cycle arrestphenanthridinetopoisomerase

Identifiers

PMID31058081
PMCPMC6478010

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.