ArticleAnemia2019
A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia.
Article in Anemia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- [Clinical characteristics and relevant factors of rheumatoid arthritis patients with anemia of chronic disease].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- The diagnostic accuracy of serum and synovial inflammatory markers in chronic periprosthetic joint infection among anaemic patients.Bone & joint research · 2026Article
- Associations of blood cell indices with the severity of rheumatoid arthritis: a retrospective case-control and machine learning modeling study.Therapeutic advances in musculoskeletal disease · 2026Article
- Association of NLR and Ferritin in Osteoporotic Fractures Among Chinese Older Patients.Journal of inflammation research · 2025Article
- Evaluation of hematological markers as prognostic tools in rheumatoid arthritis.BMC rheumatology · 2024Article
- Extensive study of CCN4, VCAM-1, MMP-3, and GM-CSF as reliable markers for disease activity in rheumatoid arthritis.Journal of Taibah University Medical Sciences · 2024Article
- Diet affects inflammatory arthritis: a Mendelian randomization study of 30 dietary patterns causally associated with inflammatory arthritis.Frontiers in nutrition · 2024Article
- Development and validation of a predictive model assessing the risk of sarcopenia in rheumatoid arthritis patients.Frontiers in immunology · 2024Article
- Extensive Study on Hematological, Immunological, Inflammatory Markers, and Biochemical Profile to Identify the Risk Factors in COVID-19 Patients.International journal of inflammation · 2022Article
- Occupational exposure to gasoline in gasoline station male attendants promotes M1 polarization in macrophages.Environmental science and pollution research international · 2022Article
- Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected withVeterinary world · 2021Article
- Erythroferrone Expression in Anemic Rheumatoid Arthritis Patients: Is It Disordered Iron Trafficking or Disease Activity?Journal of inflammation research · 2021Article
- The correlation between vitamin a status and refractory Mycoplasma Pneumoniae pneumonia (RMPP) incidence in children.BMC pediatrics · 2020Article
- Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy.BMC complementary medicine and therapies · 2020Article
- High Dose of Intravenous Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells (CLV-100) Infusion Displays Better Immunomodulatory Effect among Healthy Volunteers: A Phase 1 Clinical Study.Stem cells international · 2020Article
- Impact of Petroleum Exposure on Some Hematological Indices, Interleukin-6, and Inflammatory Markers of Workers at Petroleum Stations in Basra City.Journal of environmental and public health · 2020Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin-6 (IL-6) proinflammatory cytokine is associated with the pathogenesis of rheumatoid arthritis and development of anemia in it. This is a comparative study of inflammatory and hematological parameters in RA patients with anemia of chronic disease (ACD) and iron deficiency anemia (IDA). It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status.
methodsThe study included 89 patients from both sexes divided into four groups (group 1: 30 iron deficiency anemia (IDA), 59 RA; group 2: 20 RA-COMBI; group 3: 23 RA-ACD; and group 4: 16 nonanemic RA). These different groups were compared with a healthy group of 50 healthy individuals. Different blood parameters (WBC, RBC, HGB, HCT, MCV, and MCH) have been evaluated. Serum concentrations of IL-6, hsCRP, anti-CCP, and ferritin were measured in all patients and healthy individual using enzyme-linked immunosorbent assay ELISA.
resultsThere were significant changes in most of blood parameters between the groups, and there was a significant increase in the levels of IL-6 among RA patients. This increase was highly significant among RA-ACD patients in particular, and this elevation has been directly correlated with clinical indices of disease activity such as hsCRP, ESR, anti-CCP, and ferritin. There was an inverse relationship between ferritin and all iron status parameter, such as RBC, HGB, and haematocrit.
conclusionIL-6 and ferritin level estimation may be workable tests to differentiate the patients with IDA and ACD in RA.
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Registered trials
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