Evidence map›Paper›PMID 31057917›Full record

ArticleMicrosystems & nanoengineering2018

Design rules for a tunable merged-tip microneedle.

Jungeun Lim, Dongha Tahk, James Yu, Dal-Hee Min, Noo Li Jeon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microsystems & nanoengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  4. Article
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  6. Recent advances of microneedles biosensors for plants.Analytical and bioanalytical chemistry · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Advances of Microneedles in Biomedical Applications.Molecules (Basel, Switzerland) · 2021
    Review
  13. Review
  14. Review
  15. Review
  16. Microneedle arrays for the treatment of chronic wounds.Expert opinion on drug delivery · 2020
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jungeun Lim *1School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, 08826 South Korea.
Dongha Tahk *1School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, 08826 South Korea.ORCID 0000-0002-1245-4021
James Yu4Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826 South Korea.
Dal-Hee Min5Department of Chemistry, Seoul National University, Seoul, South Korea.
Noo Li Jeon1School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, 08826 South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This publication proposes the use of an elasto-capillarity-driven self-assembly for fabricating a microscale merged-tip structure out of a variety of biocompatible UV-curable polymers for use as a microneedle platform. In addition, the novel merged-tip microstructure constitutes a new class of microneedles, which incorporates the convergence of biocompatible polymer micropillars, leading to the formation of a sharp tip and an open cavity capable of both liquid trapping and volume control. When combined with biocompatible photopolymer micropillar arrays fabricated with photolithography, elasto-capillarity-driven self-assembly provides a means for producing a complex microneedle-like structure without the use of micromolding or micromachining. This publication also explores and defines the design rules by which several fabrication aspects, such as micropillar dimensions, shapes, pattern array configurations, and materials, can be manipulated to produce a customizable microneedle array with controllable cavity volumes, fracture points, and merge profiles. In addition, the incorporation of a modular through-hole micropore membrane base was also investigated as a method for constitutive payload delivery and fluid-sampling functionalities. The flexibility and fabrication simplicity of the merged-tip microneedle platform holds promise in transdermal drug delivery applications.

Identifiers

PMID31057917
PMCPMC6220166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.