ArticleMicrosystems & nanoengineering2018
Sheathless inertial cell focusing and sorting with serial reverse wavy channel structures.
Article in Microsystems & nanoengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Ridge-assisted micro positioning of cells in a channel.Science advances · 2026Article
- 3D-Printed Closed-Channel Spiral Inertial Microfluidic Device for Size-Based Particle Separation.Micromachines · 2026Article
- Pressurized photobonding for 3D-printed inertial and droplet microfluidics.Lab on a chip · 2025Article
- A Numerical and Experimental Study on the Enrichment Performance of a Novel Multi-Physics Coupling Microchannel.Micromachines · 2025Article
- Ridge-assisted Micro Positioning of Cells and Particles in a Microchannel.bioRxiv : the preprint server for biology · 2025Article
- Design and Performance Analysis of Spiral Microchannels for Efficient Particle Separation Using Inertial Microfluidics.Micromachines · 2025Article
- A Novel Size-Based Centrifugal Microfluidic Design to Enrich and Magnetically Isolate Circulating Tumor Cells from Blood Cells through Biocompatible Magnetite-Arginine Nanoparticles.Sensors (Basel, Switzerland) · 2024Article
- A High-Throughput Circular Tumor Cell Sorting Chip with Trapezoidal Cross Section.Sensors (Basel, Switzerland) · 2024Article
- Human leucocytes processed by fast-rate inertial microfluidics retain conventional functional characteristics.Journal of the Royal Society, Interface · 2024Article
- Enhancing particle focusing: a comparative experimental study of modified square wave and square wave microchannels in lift and Dean vortex regimes.Scientific reports · 2024Article
- Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput.Microsystems & nanoengineering · 2024Article
- Low-cost inertial microfluidic device for microparticle separation: A laser-Ablated PMMA lab-on-a-chip approach without a cleanroom.HardwareX · 2023Article
- Blood component separation in straight microfluidic channels.Biomicrofluidics · 2023Article
- Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review.Sensors (Basel, Switzerland) · 2023Review
- Dean-Flow Affected Lateral Focusing and Separation of Particles and Cells in Periodically Inhomogeneous Microfluidic Channels.Sensors (Basel, Switzerland) · 2023Article
- Sheathless inertial particle focusing methods within microfluidic devices: a review.Frontiers in bioengineering and biotechnology · 2023Review
- Asymmetrical Obstacles Enable Unilateral Inertial Focusing and Separation in Sinusoidal Microchannel.Cyborg and bionic systems (Washington, D.C.) · 2023Article
- Recent Advances in Microfluidic Platform for Physical and Immunological Detection and Capture of Circulating Tumor Cells.Biosensors · 2022Review
- Particle Focusing in a Straight Microchannel with Non-Rectangular Cross-Section.Micromachines · 2022Article
- Methods of Generating Dielectrophoretic Force for Microfluidic Manipulation of Bioparticles.ACS biomaterials science & engineering · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inertial microfluidics utilizing passive hydrodynamic forces has been attracting significant attention in the field of precise microscale manipulation owing to its low cost, simplicity and high throughput. In this paper, we present a novel channel design with a series of reverse wavy channel structures for sheathless inertial particle focusing and cell sorting. A single wavy channel unit consists of four semicircular segments, which produce periodically reversed Dean secondary flow along the cross-section of the channel. The balance between the inertial lift force and the Dean drag force results in deterministic equilibrium focusing positions, which also depends on the size of the flow-through particles and cells. Six sizes of fluorescent microspheres (15, 10, 7, 5, 3 and 1 μm) were used to study the size-dependent inertial focusing behavior. Our novel design with sharp-turning subunits could effectively focus particles as small as 3 μm, the average size of platelets, enabling the sorting of cancer cells from whole blood without the use of sheath flows. Utilizing an optimized channel design, we demonstrated the size-based sorting of MCF-7 breast cancer cells spiked in diluted whole blood samples without using sheath flows. A single sorting process was able to recover 89.72% of MCF-7 cells from the original mixture and enrich MCF-7 cells from an original purity of 5.3% to 68.9% with excellent cell viability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.