Evidence map›Paper›PMID 31057882›Full record

ArticleMicrosystems & nanoengineering2017

A microscale optical implant for continuous

Jeong Oen Lee, Haeri Park, Juan Du, Ashwin Balakrishna, Oliver Chen, David Sretavan, Hyuck Choo

Open access · goldAbstract read
In one paragraph

Article in Microsystems & nanoengineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Metasurface-Embedded Contact Lenses for Holographic Light Projection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. The application of impantable sensors in the musculoskeletal system: a review.Frontiers in bioengineering and biotechnology · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jeong Oen LeeDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA 91106, USA.
Haeri ParkDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA 91106, USA.
Juan DuDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA.
Ashwin BalakrishnaDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA 91106, USA.
Oliver ChenDepartment of Electrical Engineering, California Institute of Technology, Pasadena, CA 91106, USA.
David SretavanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA.
Hyuck ChooDepartment of Medical Engineering, California Institute of Technology, Pasadena, CA 91106, USA.
California Institute of Technology · USUniversity of California, San Francisco · US

Funding

Intraocular Pressure Sensing Using LightR01EY024582 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOO, HYUCK, SRETAVAN, DAVID W · 2016 to 2018
$989k
NEI NIH HHS R01 EY024582
6 · The paper itself

Abstract

Intraocular pressure (IOP) is a key clinical parameter in glaucoma management. However, despite the potential utility of daily measurements of IOP in the context of disease management, the necessary tools are currently lacking, and IOP is typically measured only a few times a year. Here we report on a microscale implantable sensor that could provide convenient, accurate, on-demand IOP monitoring in the home environment. When excited by broadband near-infrared (NIR) light from a tungsten bulb, the sensor's optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP. NIR light is minimally absorbed by tissue and is not perceived visually. The sensor's nanodot-enhanced cavity allows for a 3-5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0-40 mm Hg. Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits. Implanted sensors provided continuous

Indexed as

glaucomaintraocular pressure (IOP)in vivo continuous monitoringmicroscale sensor implantminimally invasivenear-infrared (NIR) broadband lightremote optical readout

Identifiers

PMID31057882
PMCPMC6445001
OpenAlexW2772826058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.