ArticleMicrosystems & nanoengineering2017
Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide.
Article in Microsystems & nanoengineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 77 citations in OpenAlex.
- HAntioxidants (Basel, Switzerland) · 2026Article
- Exhaled Breath Analysis: From Laboratory Test to Wearable Sensing.IEEE reviews in biomedical engineering · 2025Review
- Bio-Inspired Neuromorphic Sensory Systems from Intelligent Perception to Nervetronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Ultra-sensitive nitrate-ion detection via transconductance-enhanced graphene ion-sensitive field-effect transistors.Microsystems & nanoengineering · 2024Article
- Molecularly specific detection towards trace nitrogen dioxide by utilizing Schottky-junction-based Gas Sensor.Nature communications · 2024Article
- A new label free spiral sensor using impedance spectroscopy to characterize hepatocellular carcinoma in tissue and serum samples.Scientific reports · 2024Article
- The State of the Art on Graphene-Based Sensors for Human Health Monitoring through Breath Biomarkers.Sensors (Basel, Switzerland) · 2023Review
- Fabrication of a Disposable Amperometric Sensor for the Determination of Nitrite in Food.Micromachines · 2023Article
- Research progress of electronic nose technology in exhaled breath disease analysis.Microsystems & nanoengineering · 2023Review
- Detection of respiratory inflammation biomarkers in non-processed exhaled breath condensate samples using reduced graphene oxide.RSC advances · 2022Article
- The effect of side chain engineering on conjugated polymers in organic electrochemical transistors for bioelectronic applications.Journal of materials chemistry. C · 2022Review
- Review on oxidative stress relation on COVID-19: Biomolecular and bioanalytical approach.International journal of biological macromolecules · 2021Review
- Investigating the relationship between particulate matter and inflammatory biomarkers of exhaled breath condensate and blood in healthy young adults.Scientific reports · 2021Article
- Multi-frequency impedance sensing for detection and sizing of DNA fragments.Scientific reports · 2021Article
- Electronic Nose: Recent Developments in Gas Sensing and Molecular Mechanisms of Graphene Detection and Other Materials.Materials (Basel, Switzerland) · 2019Review
- High-sensitivity ion detection at low voltages with current-driven organic electrochemical transistors.Nature communications · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We present a portable non-invasive approach for measuring indicators of inflammation and oxidative stress in the respiratory tract by quantifying a biomarker in exhaled breath condensate (EBC). We discuss the fabrication and characterization of a miniaturized electrochemical sensor for detecting nitrite content in EBC using reduced graphene oxide. The nitrite content in EBC has been demonstrated to be a promising biomarker of inflammation in the respiratory tract, particularly in asthma. We utilized the unique properties of reduced graphene oxide (rGO); specifically, the material is resilient to corrosion while exhibiting rapid electron transfer with electrolytes, thus allowing for highly sensitive electrochemical detection with minimal fouling. Our rGO sensor was housed in an electrochemical cell fabricated from polydimethyl siloxane (PDMS), which was necessary to analyze small EBC sample volumes. The sensor is capable of detecting nitrite at a low over-potential of 0.7 V with respect to an Ag/AgCl reference electrode. We characterized the performance of the sensors using standard nitrite/buffer solutions, nitrite spiked into EBC, and clinical EBC samples. The sensor demonstrated a sensitivity of 0.21 μA μM
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.