ArticleMicrosystems & nanoengineering2016
Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding.
Article in Microsystems & nanoengineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Neuromorphic tissues: Soft biomolecular networks for brain-inspired temporal computing.Science advances · 2026Article
- Mechanochromic, Low-Cost, and Structurally Colored Displays Using Biodegradable Hydroxypropyl Cellulose.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Enhanced operation of female reproductive microphysiological system (MPS) for rapid mechanistic study.Micro and nano systems letters · 2025Article
- Dimension compensation of printed master molds by a desktop LCD 3D printer for high-precision microfluidic applications.Mikrochimica acta · 2024Article
- A Rapid Prototyping Approach for Multi-Material, Reversibly Sealed Microfluidics.Micromachines · 2023Article
- Programmable Control of Nanoliter Droplet Arrays using Membrane Displacement Traps.Advanced materials technologies · 2023Article
- A Non-Sacrificial 3D Printing Process for Fabricating Integrated Micro/Mesoscale Molds.Micromachines · 2023Article
- Hydrogel-Assisted Double Molding Enables Rapid Replication of Stereolithographic 3D Prints for Engineered Tissue Design.ACS applied materials & interfaces · 2023Article
- Micropatterning of functional lipid bilayer assays for quantitative bioanalysis.Biomicrofluidics · 2023Article
- Modular microfluidics for life sciences.Journal of nanobiotechnology · 2023Review
- 3D free-assembly modular microfluidics inspired by movable type printing.Microsystems & nanoengineering · 2023Article
- Precision enhanced alignment bonding technique with sacrificial strategy.Frontiers in bioengineering and biotechnology · 2023Article
- Modular Microfluidics: Current Status and Future Prospects.Micromachines · 2022Review
- Patient-specific brain arteries molded as a flexible phantom model using 3D printed water-soluble resin.Scientific reports · 2022Article
- 3D-printed electrochemical platform with multi-purpose carbon black sensing electrodes.Mikrochimica acta · 2022Article
- Systematic characterization of cleanroom-free fabricated macrovalves, demonstrating pumps and mixers for automated fluid handling tuned for organ-on-chip applications.Microsystems & nanoengineering · 2022Article
- Advanced microfluidic devices for fabricating multi-structural hydrogel microsphere.Exploration (Beijing, China) · 2021Review
- A Novel On-Chip Liquid-Metal-Enabled Microvalve.Micromachines · 2021Article
- Upscaling of pneumatic membrane valves for the integration of 3D cell cultures on chip.Lab on a chip · 2021Article
- PDMS Curing Inhibition on 3D-Printed Molds: Why? Also, How to Avoid It?Analytical chemistry · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined processes. Here, three-dimensional (3D) printed polymer molds are used to construct multilayer poly(dimethylsiloxane) (PDMS) devices by employing unique molding, bonding, alignment, and rapid assembly processes. Specifically, a novel single-layer, two-sided molding method is developed to realize two channel levels, non-planar membranes/valves, vertical interconnects (vias) between channel levels, and integrated inlet/outlet ports for fast linkages to external fluidic systems. As a demonstration, a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure, illustrating a high degree of flow rate control. In addition, multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic channels. Using integrated alignment marks to accurately position both stamps and individual layers, this technique is demonstrated by rapidly assembling a six-layer microfluidic device. By combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS, this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.