Evidence map›Paper›PMID 31057761›Full record

ArticleChemical science2019

A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanes.

Eugene Chong, Bo Qu, Yongda Zhang, Zachary P Cannone, Joyce C Leung, Sergei Tcyrulnikov, Khoa D Nguyen, Nizar Haddad, Soumik Biswas, Xiaowen Hou and 7 more

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts.Synlett : accounts and rapid communications in synthetic organic chemistry · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Eugene ChongChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.ORCID 0000-0002-5038-0131
Bo QuChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.ORCID 0000-0001-7347-0108
Yongda ZhangChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.ORCID 0000-0002-2575-7590
Zachary P CannoneChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.
Joyce C LeungChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.
Sergei TcyrulnikovDepartment of Chemistry , University of Pennsylvania Philadelphia , PA 19104 , USA . Email: marisa@sas.upenn.edu.
Khoa D NguyenChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.ORCID 0000-0003-2419-9854
Nizar HaddadChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.
Soumik BiswasChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.
Xiaowen HouChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.
Katarzyna KaczanowskaApeiron Synthesis S.A. Wroclaw Technology Park ul , Duńska 9 , 54-427 Wrocław , Poland.
Michał ChwalbaApeiron Synthesis S.A. Wroclaw Technology Park ul , Duńska 9 , 54-427 Wrocław , Poland.
Andrzej TraczApeiron Synthesis S.A. Wroclaw Technology Park ul , Duńska 9 , 54-427 Wrocław , Poland.
Stefan CzarnockiApeiron Synthesis S.A. Wroclaw Technology Park ul , Duńska 9 , 54-427 Wrocław , Poland.
Jinhua J SongChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.
Marisa C KozlowskiDepartment of Chemistry , University of Pennsylvania Philadelphia , PA 19104 , USA . Email: marisa@sas.upenn.edu.ORCID 0000-0002-4225-7125
Chris H SenanayakeChemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Ridgebury Road , Ridgefield , CT 06877 , USA . Email: eugene.chong@boehringer-ingelheim.com ; Email: bo.qu@boehringer-ingelheim.com ; Email: yongda.zhang@boehringer-ingelheim.com.

Funding

Computational Methods for Selective CatalysisR01GM087605 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KOZLOWSKI, MARISA C · 2010 to 2019
$2.4M
NIGMS NIH HHS R01 GM087605
6 · The paper itself

Abstract

We report the synthesis of enantiomerically enriched 1,4-benzodioxanes containing alkyl, aryl, heteroaryl, and/or carbonyl substituents at the 2-position. The starting 1,4-benzodioxines were readily synthesized

Identifiers

PMID31057761
PMCPMC6472100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.