ArticleChemical science2019
Synthesis of lamellarin alkaloids using orthoester-masked α-keto acids.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- Lewis Acid-Catalyzed Chemoselective Reduction of β,γ-Unsaturated-α-Keto Esters with Hantzsch's Ester.Tetrahedron letters · 2026Article
- Marine Natural Products in Preclinical Cancer Studies: Ten Years of Advanced Total Synthesis.Marine drugs · 2025Review
- An Overview on the Synthesis of Lamellarins and Related Compounds with Biological Interest.Molecules (Basel, Switzerland) · 2024Review
- Design, synthesis, and exploration of antibacterial activity of 6RSC advances · 2024Article
- Pyrrolo[2,1-RSC advances · 2024Review
- Acid-Promoted Redox-Annulation toward 1,2-Disubstituted-5,6-dihydropyrrolo[2,1-α]isoquinolines: Synthesis of the Lamellarin Core.ACS omega · 2022Article
- Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products.Chemical science · 2021Article
- Marine Pyrrole Alkaloids.Marine drugs · 2021Review
- Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media.RSC advances · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyruvic acid and other α-keto acids are frequently encountered as intermediates in metabolic pathways, yet their application in total synthesis has met with limited success. In this work, we present a bioinspired strategy that utilizes highly functionalized OBO (oxabicyclo[2.2.2]octyl) orthoester masked α-ketoacids as key intermediates for the construction of both type I and II lamellarin alkaloids. Lamellarin D was synthesized,
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Registered trials
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