ReviewFrontiers in neuroscience2019
Implantable Direct Current Neural Modulation: Theory, Feasibility, and Efficacy.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- Self-Organized Nanoplasmonic Artificial Leaf for Hot-Carrier Bioelectronic Interfaces.Nature photonics · 2026Article
- Biological performance evaluation of graphene nanoplatelets for intracranial direct current stimulation.Frontiers in neuroscience · 2026Article
- Temporal properties of direct current sensory block of the rat sciatic nerve using the C-fiber reflex.Journal of neural engineering · 2025Article
- Ionic Direct Current Enables Millimeter- and Millisecond-Scale Cortical Gain Control in vivo.bioRxiv : the preprint server for biology · 2025Article
- Closed-loop electrical block of vagus nerve scales from rodent to porcine cardiac models.Journal of neural engineering · 2025Article
- Miniaturized Iontronic Micropipettes for Precise and Dynamic Ionic Modulation of Neuronal and Astrocytic Activity.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Temporal properties of transcutaneous direct current motor conduction block.Journal of neural engineering · 2025Article
- Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part I: Principles of Electrical Neuromodulation and Adverse Effects.Bioelectromagnetics · 2025Review
- Computational insights into magnetoelectric nanoparticles for neural stimulation.Frontiers in neuroscience · 2025Article
- Review
- Understanding novel neuromodulation pathways in tDCS: brain stem recordings in rats during trigeminal nerve direct current stimulation.Translational psychiatry · 2024Article
- Exploring Present and Future Directions in Nano-Enhanced Optoelectronic Neuromodulation.Accounts of chemical research · 2024Review
- Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain.Journal of neural engineering · 2024Article
- Galvanic vs. pulsatile effects on decision-making networks: reshaping the neural activation landscape.Journal of neural engineering · 2024Article
- Aligned Bioelectronic Polypyrrole/Collagen Constructs for Peripheral Nerve Interfacing.Advanced engineering materials · 2024Article
- Advances in the Regulation of Neural Function by Infrared Light.International journal of molecular sciences · 2024Review
- Cytoelectric coupling: Electric fields sculpt neural activity and "tune" the brain's infrastructure.Progress in neurobiology · 2023Article
- The Significance of Concentration-dependent Components in Computational Models of C-Fibers.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023Article
- A Cuff Lead for Delivering Ionic Direct Current (iDC) to Block Neural Activities of Sciatic Nerve.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023Article
- Neuromodulation and memory: exploring ethical ramifications in memory modification treatment via implantable neurotechnologies.Frontiers in psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Implantable neuroprostheses such as cochlear implants, deep brain stimulators, spinal cord stimulators, and retinal implants use charge-balanced alternating current (AC) pulses to recover delivered charge and thus mitigate toxicity from electrochemical reactions occurring at the metal-tissue interface. At low pulse rates, these short duration pulses have the effect of evoking spikes in neural tissue in a phase-locked fashion. When the therapeutic goal is to suppress neural activity, implants typically work indirectly by delivering excitation to populations of neurons that then inhibit the target neurons, or by delivering very high pulse rates that suffer from a number of undesirable side effects. Direct current (DC) neural modulation is an alternative methodology that can directly modulate extracellular membrane potential. This neuromodulation paradigm can excite or inhibit neurons in a graded fashion while maintaining their stochastic firing patterns. DC can also sensitize or desensitize neurons to input. When applied to a population of neurons, DC can modulate synaptic connectivity. Because DC delivered to metal electrodes inherently violates safe charge injection criteria, its use has not been explored for practical applicability of DC-based neural implants. Recently, several new technologies and strategies have been proposed that address this safety criteria and deliver ionic-based direct current (iDC). This, along with the increased understanding of the mechanisms behind the transcutaneous DC-based modulation of neural targets, has caused a resurgence of interest in the interaction between iDC and neural tissue both in the central and the peripheral nervous system. In this review we assess the feasibility of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.