ArticleProceedings of SPIE--the International Society for Optical Engineering2019
Validation of tissue optical properties measurement using diffuse reflectance spectroscopy (DRS).
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Monte Carlo modeling and phantom studies show Cherenkov emission per unit dose during total skin electron therapy is a function of tissue optical properties.Medical physics · 2026Article
- Fluorescence spectroscopy precorrection model robust to large variability of optical properties: application to point of care quantitative liver graft viability assessment.Biomedical optics express · 2026Article
- A novel investigational preclinical model to assess fluence rate for dental oral craniofacial tissues.Photodiagnosis and photodynamic therapy · 2024Article
- In vivo spectroscopic evaluation of human tissue optical properties and hemodynamics during HPPH-mediated photodynamic therapy of pleural malignancies.Journal of biomedical optics · 2022Article
- Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study.Journal of biomedical optics · 2022Article
- A Comparison of Two Probes to Determine Rectum Optical Properties.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Determination of the distribution of drug concentration and tissue optical properties for ALA-mediated anal photodynamic therapy.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- In vivo Spectroscopic Evaluation of the Intraperitoneal Cavity in Canines.Photochemistry and photobiology · 2020Article
- Validating Homogeneity for a Novel 3-Dimensional Tissue Phantom Modeling System of the Human Maxilla.Proceedings of SPIE--the International Society for Optical EngineeringArticle
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Authors and funding
3 authors.
Funding
Abstract
The effectiveness of photodynamic treatment depends on several factors including an accurate knowledge of optical properties of the tissue to be treated. Transmittance and diffuse reflectance spectroscopic techniques are commonly used to determine tissue optical properties. Although transmittance spectroscopy technique is accurate in determining tissue optical properties, it is only valid in an infinite medium and can only be used for interstitial measurements. Diffuse reflectance spectroscopy, on the other hand, is easily adapted to most tissue geometries including skin measurements that involve semi-infinte medium. However, the accuracy of the measured optical properties can be affected by uncertainty in the measurements themselves and/or due to the uncertainty in the fitting algorithm. In this study, we evaluate the accuracy of optical properties determination using diffuse reflectance spectroscopy implemented using a contact probe setup. We characterized the error of the optical properties fitted using two fitting algorithms, a wavelength wise fitting algorithm and a full reflectance spectral fitting algorithm. By conducting systematic investigation of the measurements and fitting algorithm of DRS, we gained an understanding of the uncertainties in the measured optical properties and outlined improvement measures to minimize these errors.
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