ArticleJournal of the American Heart Association2019
Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Intracranial Arterial Calcification on Computed Tomography and Risk of Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis.Cerebrovascular diseases (Basel, Switzerland) · 2026Pooled it
- Association between ePWV and delirium risk in icu sepsis patients: a retrospective analysis based on the MIMIC database and development of a predictive model.Clinics (Sao Paulo, Brazil) · 2026Article
- Systemic proportional pulse index is associated with incident probable dementia: aJournal of geriatric neurology · 2026Article
- Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026Review
- Severity of Intracranial Arterial Calcification on Computed Tomography and Risk of Dementia in Patients With Stroke or Transient Ischemic Attack: A Population-Based Study.Journal of the American Heart Association · 2026Article
- Pericarotid fat density: a novel predictor of cognitive and functional outcomes in cerebral small vessel disease.Frontiers in aging neuroscience · 2026Article
- Intraoperative transit-time flowmetry of the superficial temporal artery directly predicts and may mitigate risk of postoperative hyperperfusion syndrome in moyamoya bypass surgery.Frontiers in neurology · 2026Article
- Calcification of the Internal Carotid Artery and Its Influence on the Severity of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage.Journal of clinical medicine · 2025Article
- The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure.American journal of physiology. Heart and circulatory physiology · 2025Article
- Estimated pulse wave velocity and incident cognitive impairment risk in stroke patients: a longitudinal cohort study.BMC cardiovascular disorders · 2025Article
- Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function.The Journal of nutrition · 2025Article
- Vasoconstriction-inhibiting factor: an endogenous inhibitor of vascular calcification as a calcimimetic of calcium-sensing receptor.Cardiovascular research · 2025Article
- Excessive Hypercholesterolemia in Pregnancy Impairs Later-Life Maternal Vascular Function in Rats.Journal of the American Heart Association · 2025Article
- Genomic Characterisation of the Relationship and Causal Links Between Vascular Calcification, Alzheimer's Disease, and Cognitive Traits.Biomedicines · 2025Article
- Brain Ischemia in Alzheimer's Disease May Partly Counteract the Disruption of the Blood-Brain Barrier.Brain sciences · 2025Article
- Neurovascular coupling over cortical brain areas and resting state network connectivity with and without rigidified carotid artery.Neurophotonics · 2025Article
- Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes.Frontiers in aging neuroscience · 2025Article
- Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging.Frontiers in physiology · 2025Review
- Regulation of Cerebral Blood Flow Velocity by Transcutaneous Electrical Nerve Stimulation: A Preliminary Study.Healthcare (Basel, Switzerland) · 2024Article
- Association between blood-brain barrier permeability and changes in pulse wave velocity following a recent small subcortical infarct.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Background Arterial stiffness is associated with cognitive decline and dementia; however, the precise mechanisms by which it affects the brain remain unclear. Methods and Results Using a mouse model based on carotid calcification this study characterized mechanisms that could contribute to brain degeneration due to arterial stiffness. At 2 weeks postcalcification, carotid stiffness attenuated resting cerebral blood flow in several brain regions including the perirhinal/entorhinal cortex, hippocampus, and thalamus, determined by autoradiography ( P<0.05). Carotid calcification impaired cerebral autoregulation and diminished cerebral blood flow responses to neuronal activity and to acetylcholine, examined by laser Doppler flowmetry ( P<0.05, P<0.01). Carotid stiffness significantly affected spatial memory at 3 weeks ( P<0.05), but not at 2 weeks, suggesting that cerebrovascular impairments precede cognitive dysfunction. In line with the endothelial deficits, carotid stiffness led to increased blood-brain barrier permeability in the hippocampus ( P<0.01). This region also exhibited reductions in vessel number containing collagen IV ( P<0.01), as did the somatosensory cortex ( P<0.05). No evidence of cerebral microhemorrhages was present. Carotid stiffness did not affect the production of mouse amyloid-β (Aβ) or tau phosphorylation, although it led to a modest increase in the Aβ40/Aβ42 ratio in frontal cortex ( P<0.01). Conclusions These findings suggest that carotid stiffness alters brain microcirculation and increases blood-brain barrier permeability associated with cognitive impairments. Therefore, arterial stiffness should be considered a relevant target to protect the brain and prevent cognitive dysfunctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.