Evidence map›Paper›PMID 31056949›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2020

Adverse events associated with weight-based, high-dose montelukast exposures in children.

Donald H Arnold, Nena Bowman, Theodore F Reiss, Tina V Hartert, Wendell S Akers, Donna L Seger

Erratum issued Registry-linked trialOpen access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05819541 (Dose Escalation Clinical Trial of High-dose Oral Montelukast to Inform Future RCT in Children With Acute Asthma Exacerbations), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05819541 phase2completednot on this mapstarted 2023, after this paper: background citation

Dose Escalation Clinical Trial of High-dose Oral Montelukast to Inform Future RCT in Children With Acute Asthma Exacerbations

TypeinterventionalSponsorVanderbilt University Medical CenterRan2023 to 2026Enrolled90ConditionsStatus AsthmaticusArmsMontelukast Oral Granules, Albuterol, Corticosteroid
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Donald H ArnoldDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0001-8694-4288
Nena BowmanTennessee Poison Center, Nashville, TN, USA.
Theodore F ReissCelgene Corporation, Summit, NJ, USA.
Tina V HartertCenter for Asthma Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
Wendell S AkersDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Donna L SegerDepartment of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Vanderbilt University · USLipscomb University · USWashington Poison Center · US

Funding

Midcareer Investigator Patient-oriented Research Award in Bronchiolitis & AsthmaK24AI077930 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTERT, TINA V · 2008 to 2017
$1.6M
NIAID NIH HHS K24 AI077930
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetatesAsthmaBody WeightChildCyclopropanesDose-Response Relationship, DrugDrug Dosage CalculationsFemaleHumansLeukotriene AntagonistsMalePoison Control CentersQuinolinesSulfidesAcetatesCyclopropanesLeukotriene AntagonistsmontelukastQuinolinesSulfides

Identifiers

PMID31056949
PMCPMC7314285
OpenAlexW2943929920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.