Evidence map›Paper›PMID 31056901›Full record

ArticleAnalytical chemistry2019

3D Printed Microfluidic Devices for Microchip Electrophoresis of Preterm Birth Biomarkers.

Michael J Beauchamp, Anna V Nielsen, Hua Gong, Gregory P Nordin, Adam T Woolley

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 80 citations in OpenAlex.

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  20. Fully 3D printed fluidic devices with integrated valves and pumps for flow injection analysis.Analytical methods : advancing methods and applications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael J Beauchamp
Anna V Nielsen
Hua Gong
Gregory P Nordin
Brigham Young University · US

Funding

Phase-Changing Sacrificial Layer Microfluidics for Enhanced Protein AnalysisR01EB006124 · NIBIB · BRIGHAM YOUNG UNIVERSITY · PI WOOLLEY, ADAM THOMAS · 2006 to 2016
$3.1M
High Density 3D Printed Microfluidics With Open Source Resins for Biomedical ApplicationsR15GM123405 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI NORDIN, GREGORY P. · 2017 to 2023
$1.3M
3D-Printed Integrated Microfluidic Devices for Preterm Birth Biomarker AnalysisR01EB027096 · NIBIB · BRIGHAM YOUNG UNIVERSITY · PI WOOLLEY, ADAM THOMAS · 2018 to 2021
$1.1M
NIBIB NIH HHS R01 EB006124NIBIB NIH HHS R01 EB027096NIGMS NIH HHS R15 GM123405
6 · The paper itself

Abstract

This work demonstrates for the first time the creation of microchip electrophoresis devices with ∼50 μm cross-sectional dimensions by stereolithographic 3D printing and their application in the analysis of medically significant biomarkers related to risk for preterm birth (PTB). We determined that device current was linear with applied potential up to 800 V (620 V/cm). We optimized device and separation conditions using fluorescently labeled amino acids as a model system and compared the performance in our 3D printed microfluidic devices to that in other device materials commonly used for microchip electrophoresis analysis. We demonstrated for the first time microchip electrophoresis in a 3D printed device of three PTB biomarkers, including peptides and a protein, with suitable separation characteristics. Limits of detection for microchip electrophoresis in 3D printed microfluidic devices were also determined for PTB biomarkers to be in the high picomolar to low nanomolar range.

Indexed as

Electrophoresis, MicrochipLab-On-A-Chip DevicesPrinting, Three-DimensionalAmino AcidsBiomarkersFemaleFluorescent DyesHumansPregnancyPremature BirthAmino AcidsBiomarkersFluorescent Dyes

Identifiers

PMID31056901
PMCPMC6561337
OpenAlexW2942579127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.