Evidence map›Paper›PMID 31056697›Full record

ArticleThe Journal of infectious diseases2019

Infant Pneumococcal Carriage During Influenza, RSV, and hMPV Respiratory Illness Within a Maternal Influenza Immunization Trial.

Alastair F Murray, Janet A Englund, Jane Kuypers, James M Tielsch, Joanne Katz, Subarna K Khatry, Steven C Leclerq, Helen Y Chu

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01034254 (Field Trial of Maternal Influenza Immunization in Asia), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01034254 phase3completednot on this map

Field Trial of Maternal Influenza Immunization in Asia

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2010 to 2017Enrolled3,693ConditionsInfluenza HumanArmsinfluenza vaccine, saline placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alastair F MurraySchool of Medicine and Health Sciences, George Washington University, Washington, District of Columbia.
Janet A EnglundSeattle Children's Hospital, Washington.
Jane KuypersDepartment of Laboratory Medicine, University of Washington, Seattle.
James M TielschGlobal Health, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia.
Joanne KatzInternational Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Subarna K KhatryNepal Nutrition Intervention Project - Sarlahi, Kathmandu, Nepal.
Steven C LeclerqNepal Nutrition Intervention Project - Sarlahi, Kathmandu, Nepal.
Helen Y ChuDivision of Allergy and Infectious Diseases, University of Washington, Seattle.

Funding

Prospective Community-Based Study of RSV Risk Factors in Nepalese ChildrenK23AI103105 · NIAID · UNIVERSITY OF WASHINGTON · PI CHU, HELEN YING-HUI · 2013 to 2017
$897k
NIAID NIH HHS K23 AI103105
6 · The paper itself

Abstract

In this post-hoc analysis of midnasal pneumococcal carriage in a community-based, randomized prenatal influenza vaccination trial in Nepal with weekly infant respiratory illness surveillance, 457 of 605 (75.5%) infants with influenza, respiratory syncytial virus (RSV), or human metapneumovirus (hMPV) illness had pneumococcus detected. Pneumococcal carriage did not impact rates of lower respiratory tract disease for these 3 viruses. Influenza-positive infants born to mothers given influenza vaccine had lower pneumococcal carriage rates compared to influenza-positive infants born to mothers receiving placebo (58.1% versus 71.6%, P = 0.03). Maternal influenza immunization may impact infant acquisition of pneumococcus during influenza infection. Clinical Trials Registration. NCT01034254.

Indexed as

Influenza VaccinesVaccinationFemaleHumansInfantInfant, NewbornInfluenza, HumanMetapneumovirusMothersNepalParamyxoviridae InfectionsPneumococcal InfectionsPregnancyPregnancy Complications, InfectiousRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsInfluenza VaccineshMPVinfluenzamaternal immunizationpneumococcusRSVvaccine

Identifiers

PMID31056697
PMCPMC6688054

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.