ArticleInternational journal of epidemiology2019
Polygenic risk scores for Alzheimer's disease, and academic achievement, cognitive and behavioural measures in children from the general population.
Article in International journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Educational attainment and diabetes risk: triangulation evidence from UK Biobank prospective cohort, NHANES 2011-2018, and cross-trait genomics analyses.Frontiers in endocrinology · 2026Article
- Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure.Translational psychiatry · 2024Review
- Mapping Normative Trajectories of Cognitive Function and Its Relation to Psychopathology Symptoms and Genetic Risk in Youth.Biological psychiatry global open science · 2023Article
- Modern Approaches to the Diagnosis of Cognitive Impairment and Alzheimer's Disease: A Narrative Literature Review.Consortium psychiatricum · 2023Review
- Antioxidant enzyme and DNA base repair genetic risk scores' associations with systemic oxidative stress biomarker in pooled cross-sectional studies.Frontiers in aging · 2023Article
- Integration of multiple-omics data to reveal the shared genetic architecture of educational attainment, intelligence, cognitive performance, and Alzheimer's disease.Frontiers in genetics · 2023Article
- Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease.Translational psychiatry · 2022Article
- Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm.Journal of neurodevelopmental disorders · 2022Article
- Associations of DNA Base Excision Repair and Antioxidant Enzyme Genetic Risk Scores with Biomarker of Systemic Inflammation.Frontiers in aging · 2022Article
- Associations of Polygenic Risk Score for Late-Onset Alzheimer's Disease With Biomarkers.Frontiers in aging neuroscience · 2022Review
- Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.Translational psychiatry · 2021Article
- Polygenic Score Models for Alzheimer's Disease: From Research to Clinical Applications.Frontiers in neuroscience · 2021Review
- Genetic risk for Alzheimer disease in children: Evidence from early-life IQ and brain white-matter microstructure.Genes, brain, and behavior · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSeveral studies report a polygenic component of risk for Alzheimer's disease. Understanding whether this polygenic signal is associated with educational, cognitive and behavioural outcomes in children could provide an earlier window for intervention.
methodsWe examined whether polygenic risk scores (PRS) at varying P-value thresholds in children from the Avon Longitudinal Study of Parents and Children were associated with academic achievement, cognitive and behavioural measures in childhood and adolescence.
resultsWe did not detect any evidence that the genome-wide significant PRS (5x10-8) were associated with these outcomes. PRS at the highest P-value threshold examined (P ≤ 5x10-1) were associated with lower academic achievement in adolescents (Key Stage 3; β: -0.03; 95% confidence interval: -0.05, -0.003) but the effect was attenuated when single nucleotide polymorphisms (SNPs) associated with educational attainment were removed. These PRS were associated with lower IQ (β: -0.04; 95% CI: -0.07, -0.02) at age 8 years with the effect remaining after removing SNPs associated with educational attainment.
conclusionsSNPs mediating the biological effects of Alzheimer's disease are unlikely to operate early in life. The evidence of association between PRS for Alzheimer's disease at liberal thresholds and cognitive measures suggest shared genetic pathways between Alzheimer's disease, academic achievement and cognition.
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