Evidence map›Paper›PMID 31056463›Full record

ArticleCell chemical biology2019

Allosteric Regulation of Oligomerization by a B

Markus Ruetz, Gregory C Campanello, Liam McDevitt, Adam L Yokom, Pramod K Yadav, David Watkins, David S Rosenblatt, Melanie D Ohi, Daniel R Southworth, Ruma Banerjee

Open access · bronzeAbstract read
In one paragraph

Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Cobalt-Sulfur Coordination Chemistry Drives BJournal of the American Chemical Society · 2023
    Article
  2. Article
  3. Article
  4. Bivalent molecular mimicry by ADP protects metal redox state and promotes coenzyme BProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Human BMethods in enzymology · 2022
    Article
  6. The human BMethods in enzymology · 2022
    Article
  7. Redox-Linked Coordination Chemistry Directs Vitamin BAccounts of chemical research · 2021
    Article
  8. Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme BProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Markus RuetzDepartment of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI, USA.
Gregory C CampanelloDepartment of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI, USA.
Liam McDevittDepartment of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI, USA.
Adam L YokomLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Pramod K YadavLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
David WatkinsDepartment of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada.
David S RosenblattDepartment of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada.
Melanie D OhiLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel R SouthworthDepartment of Biochemistry and Biophysics, Institute for Neurodegenerative Diseases, University of California-San Francisco, San Francisco, CA 94158, USA.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI, USA. Electronic address: rbanerje@umich.edu.
University of Michigan–Ann Arbor · USMcGill University · CAUniversity of California, San Francisco · US

Funding

REACTION MECHANISMS OF MAMMALIAN B12-DEPENDENT ENZYMESR01DK045776 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI RUMA V BANERJEE · 1998 to 2026
$9.7M
Silicon Mechanics Compute ClusterS10OD020011 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2015 to 2015
$490k
Structural Enzymology of Mitochondrial B12 Trafficking ProteinsF32GM113405 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPANELLO, GREGORY · 2015 to 2016
$112k
NIDDK NIH HHS R01 DK045776NIGMS NIH HHS F32 GM113405NIH HHS S10 OD020011
6 · The paper itself

Abstract

Allosteric regulation of methylmalonyl-CoA mutase (MCM) by the G-protein chaperone CblA is transduced via three "switch" elements that gate the movement of the B

Indexed as

Allosteric RegulationAmino Acid Metabolism, Inborn ErrorsFibroblastsGuanosine TriphosphateHumansMethylmalonyl-CoA MutaseMolecular ChaperonesMutationProtein TransportVitamin B 12Guanosine TriphosphateMethylmalonyl-CoA MutaseMolecular ChaperonesVitamin B 12cblAcobalamincofactorG-proteinGTPasemetalloproteinmetal traffickingMMAAtraffickingvitamin B(12)

Identifiers

PMID31056463
PMCPMC6642015
OpenAlexW2942985774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.