ArticleCurrent biology : CB2019
A Memory Circuit for Coping with Impending Adversity.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
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- Aberrant Positions of the Chemosensory Neurons in the Neurotransmitter-Release MutantInternational journal of molecular sciences · 2024Article
- Locomotion modulates olfactory learning through proprioception in C. elegans.Nature communications · 2023Article
- Inheritance of associative memories and acquired cellular changes in C. elegans.Nature communications · 2023Article
- Why it hurts: with freedom comes the biological need for pain.Animal cognition · 2023Article
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- C. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties.Journal of cannabis research · 2022Article
- Biomolecular Basis of Cellular Consciousness via Subcellular Nanobrains.International journal of molecular sciences · 2021Review
- Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans.BMC biology · 2021Article
- Transcription Factors That Control Behavior-Lessons FromFrontiers in neuroscience · 2021Review
- A cellular defense memory imprinted by early life toxic stress.Scientific reports · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Organisms' capacity to anticipate future conditions is key for survival. Associative memories are instrumental for learning from past experiences, yet little is known about the processes that follow memory retrieval and their potential advantage in preparing for impending developments. Here, using C. elegans nematodes, we demonstrate that odor-evoked retrieval of aversive memories induces rapid and protective stress responses, which increase animal survival prospects when facing imminent adversities. The underlying mechanism relies on two sensory neurons: one is necessary during the learning period, and the other is necessary and sufficient for memory retrieval. Downstream of memory reactivation, serotonin secreted from two head neurons mediates the systemic stress response. Thus, evoking stressful memories, stored within individual sensory neurons, allows animals to anticipate upcoming dire conditions and provides a head start to initiate rapid and protective responses that ultimately increase animal fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.