ArticleCurrent biology : CB2019
Visually Guided Behavior and Optogenetically Induced Learning in Head-Fixed Flies Exploring a Virtual Landscape.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- AI-Discovered Cognitive Models Reveal Novel Insights into Human and Animal Learning.bioRxiv : the preprint server for biology · 2026Article
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- Shaping of olfactory responses by taste in a new assay for operant learning in Drosophila melanogaster.The Journal of experimental biology · 2025Article
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- Foraging as an ethological framework for neuroscience.Trends in neurosciences · 2025Review
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- Exploration-exploitation trade-off is regulated by metabolic state and taste value inbioRxiv : the preprint server for biology · 2024Article
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- Temporal effects of sugar intake on fly local search and honey bee dance behaviour.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- A perspective on neuroethology: what the past teaches us about the future of neuroethology.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Reward expectations direct learning and drive operant matching inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The influence of stimulus history on directional coding in the monarch butterfly brain.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- Displacement experiments provide evidence for path integration in Drosophila.The Journal of experimental biology · 2023Article
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- Naturalistic neuroscience and virtual reality.Frontiers in systems neuroscience · 2022Review
- Excessive energy expenditure due to acute physical restraint disrupts Drosophila motivational feeding response.Scientific reports · 2021Article
- A connectome of theeLife · 2021Article
- Classification and genetic targeting of cell types in the primary taste and premotor center of the adulteLife · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
Studying the intertwined roles of sensation, experience, and directed action in navigation has been facilitated by the development of virtual reality (VR) environments for head-fixed animals, allowing for quantitative measurements of behavior in well-controlled conditions. VR has long featured in studies of Drosophila melanogaster, but these experiments have typically allowed the fly to change only its heading in a visual scene and not its position. Here we explore how flies move in two dimensions (2D) using a visual VR environment that more closely captures an animal's experience during free behavior. We show that flies' 2D interaction with landmarks cannot be automatically derived from their orienting behavior under simpler one-dimensional (1D) conditions. Using novel paradigms, we then demonstrate that flies in 2D VR adapt their behavior in response to optogenetically delivered appetitive and aversive stimuli. Much like free-walking flies after encounters with food, head-fixed flies exploring a 2D VR respond to optogenetic activation of sugar-sensing neurons by initiating a local search, which appears not to rely on visual landmarks. Visual landmarks can, however, help flies to avoid areas in VR where they experience an aversive, optogenetically generated heat stimulus. By coupling aversive virtual heat to the flies' presence near visual landmarks of specific shapes, we elicit selective learned avoidance of those landmarks. Thus, we demonstrate that head-fixed flies adaptively navigate in 2D virtual environments, but their reliance on visual landmarks is context dependent. These behavioral paradigms set the stage for interrogation of the fly brain circuitry underlying flexible navigation in complex multisensory environments.
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31056392What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.