ArticleCurrent biology : CB2019
Diverse Food-Sensing Neurons Trigger Idiothetic Local Search in Drosophila.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- Finding a path: local search behavior of Drosophila larvae.The Journal of experimental biology · 2025Article
- Bumblebees learn to use antennal and tarsal taste to predict the presence of nectar rewards in flowers.The Journal of experimental biology · 2025Article
- Building an Egocentric-to-Allocentric Travelling Direction Transformation Model for Enhanced Navigation in Intelligent Agents.Sensors (Basel, Switzerland) · 2025Article
- Article
- Wind gates olfaction-driven search states in free flight.Current biology : CB · 2024Article
- Article
- Exploration-exploitation trade-off is regulated by metabolic state and taste value inbioRxiv : the preprint server for biology · 2024Article
- Temporal effects of sugar intake on fly local search and honey bee dance behaviour.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Emergent spatial goals in an integrative model of the insect central complex.PLoS computational biology · 2023Article
- Tracking Sugar-Elicited Local Searching Behavior in Drosophila.Journal of visualized experiments : JoVE · 2023Article
- Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila.Nature communications · 2023Article
- Displacement experiments provide evidence for path integration in Drosophila.The Journal of experimental biology · 2023Article
- Article
- Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions.Open biology · 2022Review
- Which Sugar to Take and How Much to Take? Two Distinct Decisions Mediated by Separate Sensory Channels.Frontiers in molecular neuroscience · 2022Article
- Article
- A connectome of theeLife · 2021Article
- Drosophila re-zero their path integrator at the center of a fictive food patch.Current biology : CB · 2021Article
- Correlated decision making across multiple phases of olfactory-guided search in Drosophila improves search efficiency.The Journal of experimental biology · 2021Article
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Abstract
Foraging animals may benefit from remembering the location of a newly discovered food patch while continuing to explore nearby [1, 2]. For example, after encountering a drop of yeast or sugar, hungry flies often perform a local search [3, 4]. That is, rather than remaining on the food or simply walking away, flies execute a series of exploratory excursions during which they repeatedly depart and return to the resource. Fruit flies, Drosophila melanogaster, can perform this food-centered search behavior in the absence of external landmarks, instead relying on internal (idiothetic) cues [5]. This path-integration behavior may represent a deeply conserved navigational capacity in insects [6, 7], but its underlying neural basis remains unknown. Here, we used optogenetic activation to screen candidate cell classes and found that local searches can be initiated by diverse sensory neurons. Optogenetically induced searches resemble those triggered by actual food, are modulated by starvation state, and exhibit key features of path integration. Flies perform tightly centered searches around the fictive food site, even within a constrained maze, and they can return to the fictive food site after long excursions. Together, these results suggest that flies enact local searches in response to a wide variety of food-associated cues and that these sensory pathways may converge upon a common neural system for navigation. Using a virtual reality system, we demonstrate that local searches can be optogenetically induced in tethered flies walking on a spherical treadmill, laying the groundwork for future studies to image the brain during path integration. VIDEO ABSTRACT.
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