ArticleCurrent biology : CB2019
Local and Global Influences of Visual Spatial Selection and Locomotion in Mouse Primary Visual Cortex.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice.Cell reports methods · 2026Article
- Disinhibitory signaling enables flexible coding of top-down information in cortical networks.PLoS biology · 2026Article
- Behavioural states control binocular vision through input-specific mechanisms.Nature communications · 2026Article
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention.Nature communications · 2026Article
- A standardized and reproducible behavioral protocol to elicit visual spatial attention in mice.bioRxiv : the preprint server for biology · 2025Article
- Functional architecture for speed tuning in primary visual cortex of carnivores.bioRxiv : the preprint server for biology · 2025Article
- Reward history guides focal attention in whisker somatosensory cortex.Nature communications · 2025Article
- Neural representation of self-initiated locomotion in the secondary motor cortex of mice across different environmental contexts.Communications biology · 2025Article
- Highly selective visual receptive fields in mouse frontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Interdigitating Modules for Visual Processing During Locomotion and Rest in Mouse V1.bioRxiv : the preprint server for biology · 2025Article
- Is the impact of spontaneous movements on early visual cortex species specific?Trends in neurosciences · 2025Review
- Simultaneous interneuron labeling reveals cell type-specific, population-level interactions in cortex.iScience · 2024Article
- Reward history guides focal attention in whisker somatosensory cortex.bioRxiv : the preprint server for biology · 2024Article
- Flexible neural population dynamics govern the speed and stability of sensory encoding in mouse visual cortex.Nature communications · 2024Article
- Common and distinct neural mechanisms of attention.Trends in cognitive sciences · 2024Review
- The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Simultaneous interneuron labeling reveals population-level interactions among parvalbumin, somatostatin, and pyramidal neurons in cortex.bioRxiv : the preprint server for biology · 2024Article
- Walking humans and running mice: perception and neural encoding of optic flow during self-motion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Independent response modulation of visual cortical neurons by attentional and behavioral states.Neuron · 2022Article
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Abstract
Sensory selection and movement locally and globally modulate neural responses in seemingly similar ways. For example, locomotion enhances visual responses in mouse primary visual cortex (V1), resembling the effects of spatial attention on primate visual cortical activity. However, interactions between these local and global mechanisms and the resulting effects on perceptual behavior remain largely unknown. Here, we describe a novel mouse visual spatial selection task in which animals either monitor one of two locations for a contrast change ("selective mice") or monitor both ("non-selective mice") and can run at will. Selective mice perform well only when their selected stimulus changes, giving rise to local electrophysiological changes in the corresponding hemisphere of V1 including decreased noise correlations and increased visual information. Non-selective mice perform well when either stimulus changes, giving rise to global changes across both hemispheres of V1. During locomotion, selective mice have worse behavioral performance, increased noise correlations in V1, and decreased visual information, while non-selective mice have decreased noise correlations in V1 but no change in performance or visual information. Our findings demonstrate that mice can locally or globally enhance visual information, but the interaction of the global effect of locomotion with local selection impairs behavioral performance. Moving forward, this mouse model will facilitate future studies of local and global sensory modulatory mechanisms and their effects on behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.