Evidence map›Paper›PMID 31056353›Full record

ArticleNeuron2019

Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells.

Ala Morshedian, Joanna J Kaylor, Sze Yin Ng, Avian Tsan, Rikard Frederiksen, Tongzhou Xu, Lily Yuan, Alapakkam P Sampath, Roxana A Radu, Gordon L Fain and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
  5. Review
  6. The physiology of dark adaptation: Progress and future directions.Progress in retinal and eye research · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Vitamin A supply in the eye and establishment of the visual cycle.Current topics in developmental biology · 2025
    Review
  15. Article
  16. Review
  17. Ablation of Fatty Acid Transport Protein-4 Enhances Cone Survival, M-cone Vision, and Synthesis of Cone-Tropic 9-The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ala MorshedianStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Joanna J KaylorStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Sze Yin NgStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Avian TsanStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Rikard FrederiksenStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Tongzhou XuStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Lily YuanStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Alapakkam P SampathStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Roxana A RaduStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA.
Gordon L FainStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Gabriel H TravisStein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: travis@jsei.ucla.edu.
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
Vision Science Training ProgramT32EY007026 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alapakkam P Sampath · 1985 to 2026
$5.7M
Mechanisms for Light-driven Chromophore Synthesis by Müller Cells to Regenerate Cone Opsin and Maintain Cone SensitivityR01EY024379 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TRAVIS, GABRIEL H · 2015 to 2024
$3.3M
Analyses of retinal circuits after rod rescue in a mouse model of human blindnessR01EY027193 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JEANNIE, FIELD, GREGORY DARIN · 2016 to 2020
$2.7M
Molecular Mechanisms of Photoreceptor AdaptationR01EY029817 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMPATH, ALAPAKKAM P · 2019 to 2023
$2.1M
The Role of Complement in Recessive Stargardt DiseaseR01EY025002 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RADU, ROXANA A · 2015 to 2019
$1.9M
PHYSIOLOGY OF PHOTORECEPTORSR37EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FAIN, GORDON LEE · 1990 to 1999
–
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY001844NEI NIH HHS R01 EY024379NEI NIH HHS R01 EY025002NEI NIH HHS R01 EY027193NEI NIH HHS R01 EY029817NEI NIH HHS R37 EY001844NEI NIH HHS T32 EY007026
6 · The paper itself

Abstract

While rods in the mammalian retina regenerate rhodopsin through a well-characterized pathway in cells of the retinal pigment epithelium (RPE), cone visual pigments are thought to regenerate in part through an additional pathway in Müller cells of the neural retina. The proteins comprising this intrinsic retinal visual cycle are unknown. Here, we show that RGR opsin and retinol dehydrogenase-10 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible light. Isolated retinas from Rgr+/+ and Rgr-/- mice were exposed to continuous light, and cone photoresponses were recorded. Cones in Rgr-/- retinas lost sensitivity at a faster rate than cones in Rgr+/+ retinas. A similar effect was seen in Rgr+/+ retinas following treatment with the glial cell toxin, α-aminoadipic acid. These results show that RGR opsin is a critical component of the Müller cell visual cycle and that regeneration of cone visual pigment can be driven by light.

Indexed as

2-Aminoadipic AcidAlcohol OxidoreductasesAnimalsEpendymoglial CellsExcitatory Amino Acid AntagonistsEye ProteinsLightMiceMice, KnockoutReceptors, G-Protein-CoupledRetinal Cone Photoreceptor CellsRetinal PigmentsVitamin A2-Aminoadipic AcidAlcohol OxidoreductasesExcitatory Amino Acid AntagonistsEye ProteinsG protein-coupled receptor RGRReceptors, G-Protein-CoupledRetinal Pigmentstrans-retinol dehydrogenaseVitamin A

Identifiers

PMID31056353
PMCPMC6586478
OpenAlexW2943521526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.