ArticleNeuron2019
Time Cells in the Hippocampus Are Neither Dependent on Medial Entorhinal Cortex Inputs nor Necessary for Spatial Working Memory.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Time cell sequences during delay intervals are not dependent on brain state and do not support hippocampus-dependent working memory.Nature communications · 2025Article
- The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex.PLoS biology · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Time Cells in the Retrosplenial Cortex.bioRxiv : the preprint server for biology · 2024Article
- Memory deficits and hippocampal cytokine expression in a rat model of ADHD.Brain, behavior, & immunity - health · 2024Article
- Localized APP expression results in progressive network dysfunction by disorganizing spike timing.Neuron · 2024Article
- Temporal encoding in deep reinforcement learning agents.Scientific reports · 2023Article
- A neural code for time and space in the human brain.Cell reports · 2023Article
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes.Nature communications · 2023Article
- Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience.bioRxiv : the preprint server for biology · 2023Article
- Review
- A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory.Nature communications · 2022Article
- Article
- Medial Entorhinal Cortex Excitatory Neurons Are Necessary for Accurate Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain.International journal of molecular sciences · 2021Article
- Precisely timed theta oscillations are selectively required during the encoding phase of memory.Nature neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
A key function of the hippocampus and entorhinal cortex is to bridge events that are discontinuous in time, and it has been proposed that medial entorhinal cortex (mEC) supports memory retention by sustaining the sequential activity of hippocampal time cells. Therefore, we recorded hippocampal neuronal activity during spatial working memory and asked whether time cells depend on mEC inputs. Working memory was impaired in rats with mEC lesions, but the occurrence of time cells and of trajectory-coding cells in the stem did not differ from controls. Rather, the main effect of mEC lesions was an extensive spatial coding deficit of CA1 cells, which included inconsistency over time and reduced firing differences between positions on the maze. Therefore, mEC is critical for providing stable and distinct spatial information to hippocampus, while working memory (WM) maintenance is likely supported either by local synaptic plasticity in hippocampus or by activity patterns elsewhere in the brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.