ArticlePregnancy hypertension2019
Low fetal fraction of cell-free DNA predicts placental dysfunction and hypertensive disease in pregnancy.
Article in Pregnancy hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Low fetal fraction and adverse pregnancy outcomes- systematic review of the literature and metanalysis.Archives of gynecology and obstetrics · 2024Pooled it
- Association between low fetal fraction in cell-free DNA testing and adverse pregnancy outcome: A systematic review.Prenatal diagnosis · 2021Pooled it
- Circulating Nucleic Acids in Maternal Plasma and Serum in Pregnancy Complications: Are They Really Useful in Clinical Practice? A Systematic Review.Molecular diagnosis & therapy · 2020Pooled it
- The Prediction of Pre-Eclampsia Using Low Fetal Fraction in a Machine Learning Model.Prenatal diagnosis · 2026Article
- Preeclampsia 2.0: limitations and challenges of the two-stage hypothesis, and beyond.Molecular human reproduction · 2026Review
- Extremes of Fetal Fraction on Noninvasive Prenatal Screening and Placental Histopathology: Is There an Association?Journal of clinical medicine · 2025Article
- Fetal fractions mediate the association between total cell-free DNA and preeclampsia risk in a non-invasive prenatal testing cohort.Human genomics · 2025Article
- Diagnostic Value of Cell-Free DNA Fetal Fraction in Patients With Prenatally Suspected Placenta Accreta Spectrum Disorder.Prenatal diagnosis · 2025Article
- Prediction of Preeclampsia in Twins Using First Trimester: cffDNA Fraction, PlGF, and MAP.Prenatal diagnosis · 2025Article
- Association between fetal fraction of cell-free DNA and adverse pregnancy outcomes.Archives of gynecology and obstetrics · 2024Article
- The Association between Low Fetal Fraction of Non-Invasive Prenatal Testing and Adverse Pregnancy Outcomes for Placental Compromise.Diagnostics (Basel, Switzerland) · 2024Article
- Genetic diagnosis of a rare COL7A1 variant causing dystrophic epidermolysis bullosa pruriginosa through whole‑exome sequencing.Experimental and therapeutic medicine · 2023Article
- Cell-free DNA methylome analysis for early preeclampsia prediction.Nature medicine · 2023Article
- Evaluation of The Relationship between Cell-Free DNA Fetal Fraction of The Circulatory System and Fetal and Maternal Pregnancy Prognosis: A Prospective Study.International journal of fertility & sterility · 2023Article
- Use of cell-free signals as biomarkers for early and easy prediction of preeclampsia.Frontiers in medicine · 2023Article
- Global Trends in Research on Cell-Free Nucleic Acids in Obstetrics and Gynecology during 2017-2021.Journal of clinical medicine · 2022Review
- Lower fetal fraction in clinical cell-free DNA screening results is associated with increased risk of hypertensive disorders of pregnancy.Prenatal diagnosis · 2022Article
- Association of fetal fraction with hypertensive disorders of pregnancy incidence and disease severity.American journal of obstetrics & gynecology MFM · 2022Article
- The low fetal fraction at the first trimester is associated with adverse pregnancy outcomes in IVF singleton pregnancies with single embryo transfer from frozen cycles.Journal of assisted reproduction and genetics · 2022Article
- Genetic Counseling and Management: The First Study to Report NIPT Findings in a Romanian Population.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo examine the association of low fetal fraction of cell-free DNA (cfDNA) with placental compromise and adverse perinatal outcomes. MATERIALS AND
methodsThis was a retrospective cohort utilizing a sample of convenience including 639 women undergoing cfDNA screening at our institution from January 2013 to January 2017. Low fetal fraction was defined as less than the 25th percentile. Indicators of placental compromise were examined individually and as a composite outcome, including hypertensive disease of pregnancy, intrauterine growth restriction, abruption, and oligohydramnios. Neonatal outcomes, including preterm delivery, low Apgar scores, and small for gestational age, also were examined. We calculated risk ratios (RR) and 95% confidence intervals (CI).
resultsLow fetal fraction was associated with placental compromise (RR 1.6 [CI 1.1-2.2]), hypertensive disease of pregnancy (RR 1.6 [CI 1.003-2.6]), and preeclampsia with severe features (RR 3.3 [CI 1.2-8.9]). Low fetal faction was not associated with preterm delivery, low Apgar scores, or small for gestational age.
conclusionsLow fetal fraction of cfDNA among asymptomatic women may serve as a predictor of subsequent placental dysfunction and hypertensive disease.
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