ArticleFluids and barriers of the CNS2019
Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system.
Article in Fluids and barriers of the CNS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- In-silico solute transport via perivascular networks in the human intracranial space.Nature communications · 2026Article
- Enhanced Taylor-Aris dispersion in slender pulsatile annular channels: Implications for perivascular solute transport.Journal of fluid mechanics · 2026Article
- MR-AIV reveals in vivo brain-wide fluid flow with physics-informed AI.Science advances · 2026Article
- Review
- A 3D non-human primate digital model for pharmacokinetic prediction of intra-cerebrospinal fluid drug neuraxial dispersion.Fluids and barriers of the CNS · 2025Article
- Steady streaming in channels with a porous interior.Physical review fluids · 2025Article
- MR-AIV revealsbioRxiv : the preprint server for biology · 2025Article
- Estimation of fluid flow velocities in cortical brain tissue driven by the microvasculature.Interface focus · 2025Article
- Impact of thermodynamical rotational flow of cerebrospinal fluid in the presence of elasticity.BMC research notes · 2023Article
- A novel method to quantify perivascular space enlargement near the syrinx in a rodent model of post-traumatic syringomyelia.Scientific reports · 2023Article
- Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS.Nature reviews. Neuroscience · 2023Review
- Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation.Fluids and barriers of the CNS · 2023Article
- Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow.Journal of the Royal Society, Interface · 2023Article
- Pulsatile cerebral paraarterial flow by peristalsis, pressure and directional resistance.Fluids and barriers of the CNS · 2023Article
- Perivascular network segmentations derived from high-field MRI and their implications for perivascular and parenchymal mass transport in the rat brain.Scientific reports · 2023Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- A network model of glymphatic flow under different experimentally-motivated parametric scenarios.iScience · 2022Article
- Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model.Fluids and barriers of the CNS · 2022Article
- The glymphatic hypothesis: the theory and the evidence.Fluids and barriers of the CNS · 2022Review
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3 authors.
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Abstract
backgroundAs an alternative to advection, solute transport by shear-augmented dispersion within oscillatory cerebrospinal fluid flow was investigated in small channels representing the basement membranes located between cerebral arterial smooth muscle cells, the paraarterial space surrounding the vessel wall and in large channels modeling the spinal subarachnoid space (SSS).
methodsGeometries were modeled as two-dimensional. Fully developed flows in the channels were modeled by the Darcy-Brinkman momentum equation and dispersion by the passive transport equation. Scaling of the enhancement of axial dispersion relative to molecular diffusion was developed for regimes of flow including quasi-steady, porous and unsteady, and for regimes of dispersion including diffusive and unsteady.
resultsMaximum enhancement occurs when the characteristic time for lateral dispersion is matched to the cycle period. The Darcy-Brinkman model represents the porous media as a continuous flow resistance, and also imposes no-slip boundary conditions at the walls of the channel. Consequently, predicted dispersion is always reduced relative to that of a channel without porous media, except when the flow and dispersion are both unsteady. DISCUSSION/
conclusionsIn the basement membranes, flow and dispersion are both quasi-steady and enhancement of dispersion is small even if lateral dispersion is reduced by the porous media to achieve maximum enhancement. In the paraarterial space, maximum enhancement R
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