Evidence map›Paper›PMID 31056078›Full record

ArticleJournal of medical case reports2019

Progression of coronary microvascular dysfunction to heart failure with preserved ejection fraction: a case report.

Sandy Joung, Janet Wei, Michael D Nelson, Haider Aldiwani, Chrisandra Shufelt, Balaji Tamarappoo, Daniel Berman, Louise E J Thomson, C Noel Bairey Merz

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02582021 (Women's Ischemia Syndrome Evaluation), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02582021 recruitingnot on this map

Women's Ischemia Syndrome Evaluation (WISE) - Coronary Microvascular Dysfunction (CMD) and Heart Failure With Preserved Ejection Fraction (HFpEF)

TypeobservationalSponsorCedars-Sinai Medical CenterRan2015 to 2030Enrolled220ConditionsMicrovascular Coronary Dysfunction, Cardiovascular DiseaseArmsCoronary Angiography, Coronary Reactivity Testing, Cardiac Magnetic Resonance Imaging, Cardiac Magnetic Resonance Angiography, Computed Coronary Tomographic Angiography
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sandy JoungBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA.
Janet WeiBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA.
Michael D NelsonApplied Physiology and Advanced Imaging Laboratory, Arlington, TX, 76019, USA.
Haider AldiwaniBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA.
Chrisandra ShufeltBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA.
Balaji TamarappooBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Daniel BermanBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Louise E J ThomsonBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, 127 S. San Vicente Blvd, Suite A3600, Los Angeles, CA, 90048, USA. Noel.BaireyMerz@cshs.org.ORCID http://orcid.org/0000-0002-9933-5155
Cedars-Sinai Smidt Heart Institute · USCedars-Sinai Medical Center · USAdvanced Imaging Research (United States) · US

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
CVD protection mechanisms involving ACE2/Ang-(1-7) axisR01HL056921 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K. · 1996 to 2015
$9.2M
UFRCC for Cardiovascular Cell Therapy Research NetworkUM1HL087366 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2012 to 2018
$4.7M
BRAIN ANGIOTENSIN IN HYPERTENSIVE NEURONS IN CULTURER01HL033610 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K., SUMNERS, COLIN · 1985 to 2017
$4.3M
Women's Ischemia Syndrome EvaluationU01HL064829 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F. · 2001 to 2005
$3.9M
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Renin Angiotensin for Coronary Microvascular DysfunctionU01HL064924 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2001 to 2005
$2.0M
Nitric Oxide Transport Mechanisms: Model and ExperimentsR01HL068164 · NHLBI · DREXEL UNIVERSITY · PI JARON, DOV · 2003 to 2006
$1.3M
Behavioral Medicine and Cardiovascular Research TrainingT32HL069751 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI KRANTZ, DAVID S. · 2003 to 2007
$1.2M
NCATS NIH HHS UL1TR000064NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR001427NCATS NIH HHS UL1TR001427NCRR NIH HHS M01RR000425NHLBI NIH HHS K23HL105787NHLBI NIH HHS K23 HL127262NHLBI NIH HHS N01HV68161NHLBI NIH HHS N01HV68162NHLBI NIH HHS N01HV68163NHLBI NIH HHS N01HV68164NHLBI NIH HHS R01HL090957NHLBI NIH HHS R01HL33610NHLBI NIH HHS R01HL56921NHLBI NIH HHS T32HL69751NHLBI NIH HHS U01HL64829NHLBI NIH HHS U01HL64914NHLBI NIH HHS U01HL64924NHLBI NIH HHS UM1HL087366NIA NIH HHS R03AG032631
6 · The paper itself

Abstract

backgroundIn women with evidence of ischemia and no obstructive coronary artery disease the underlying mechanism is most often attributed to coronary microvascular dysfunction. Higher rates of adverse cardiovascular events, specifically heart failure with preserved ejection fraction, are present in women with coronary microvascular dysfunction, leading to the hypothesis that coronary microvascular dysfunction may contribute to the progression of heart failure with preserved ejection fraction. A 55-year-old, Caucasian woman with a past medical history of chest pain and shortness of breath was referred to our tertiary care center and diagnosed as having coronary microvascular dysfunction by invasive coronary reactivity testing. After 10 years of follow-up care for coronary microvascular dysfunction, she presented to an emergency room in acute heart failure and was diagnosed as having heart failure with preserved ejection fraction. DISCUSSION: The current case report provides a specific example in support of existing studies that demonstrate that coronary microvascular dysfunction may be a precursor of heart failure with preserved ejection fraction. Further research is needed to establish causality and management.

trial registrationClinical Trial Registration: ClinicalTrials.gov Identifier: NCT02582021 .

Indexed as

CardiomyopathiesChest PainCoronary CirculationDisease ProgressionDyspneaEchocardiographyFemaleHeart FailureHumansMiddle AgedStroke VolumeCardiac magnetic resonance imagingCoronary microvascular dysfunctionHeart failure with preserved ejection fractionNon-obstructive coronary artery disease

Identifiers

PMID31056078
PMCPMC6501452
OpenAlexW2947189455

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.