Evidence map›Paper›PMID 31055991›Full record

ArticleJournal of the American Heart Association2019

Psychological Distress and Subsequent Cardiovascular Events in Individuals With Coronary Artery Disease.

Pratik Pimple, Bruno B Lima, Muhammad Hammadah, Kobina Wilmot, Ronnie Ramadan, Oleksiy Levantsevych, Samaah Sullivan, Jeong Hwan Kim, Belal Kaseer, Amit J Shah and 7 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 107 citations in OpenAlex.

  1. Observational
  2. Article
  3. Lifestyle medicine pillars for women's heart health.American journal of preventive cardiology · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Pratik Pimple1 Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA.
Bruno B Lima2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Muhammad Hammadah2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Kobina Wilmot2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Ronnie Ramadan2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Oleksiy Levantsevych2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Samaah Sullivan1 Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA.
Jeong Hwan Kim2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Belal Kaseer2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Amit J Shah1 Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA.
Laura Ward3 Department of Biostatistics & Bioinformatics Rollins School of Public Health Emory University Atlanta GA.
Paolo Raggi4 Mazankowski Alberta Heart Institute University of Alberta Edmonton Alberta Canada.
J Douglas Bremner5 Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta GA.
John Hanfelt3 Department of Biostatistics & Bioinformatics Rollins School of Public Health Emory University Atlanta GA.
Tene Lewis1 Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA.
Arshed A Quyyumi2 Division of Cardiology Department of Medicine Emory University Atlanta GA.
Viola Vaccarino1 Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA.
Emory University · USUniversity of Alberta · CA

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI QUYYUMI, ARSHED A · 2010 to 2015
$11.0M
Mental Stress and Myocardial Ischemia after MI: Sex Differences, Mechanisms and PrognosisR01HL109413 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2012 to 2023
$6.9M
Multidisciplinary Research Training to Reduce Inequities in Cardiovascular HealthT32HL130025 · NHLBI · EMORY UNIVERSITY · PI Tené T Lewis, Viola Vaccarino · 2016 to 2026
$6.4M
Neural Circuits in Women with Abuse and PTSDR01MH056120 · NIMH · YALE UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 1999 to 2011
$5.0M
PTSD and Ischemic Heart Disease Progression: A Longitudinal Twin StudyR01HL125246 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2015 to 2018
$3.4M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalKL2TR000455 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$2.9M
Mechanisms of Depression in CVDR01HL088726 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2008 to 2012
$2.6M
Mind-Body Interactions in Cardiovascular DiseaseK24HL077506 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2013
$1.5M
Biological Correlates of Traumatic StressK24MH076955 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2006 to 2013
$946k
Emotional Stress as a Risk Factor for Arrhythmia: Ischemic and Genetic MechanismsK23HL127251 · NHLBI · EMORY UNIVERSITY · PI SHAH, AMIT JASVANT · 2016 to 2019
$749k
NCATS NIH HHS KL2 TR000455NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL127251NHLBI NIH HHS K24 HL077506NHLBI NIH HHS P01 HL101398NHLBI NIH HHS R01 HL088726NHLBI NIH HHS R01 HL109413NHLBI NIH HHS R01 HL125246NHLBI NIH HHS T32 HL130025NIMH NIH HHS K24 MH076955NIMH NIH HHS R01 MH056120
6 · The paper itself

Abstract

Background Higher symptom levels of a variety of measures of emotional distress have been associated with cardiovascular disease ( CVD ), especially among women. Here, our goal was to investigate the association between a composite measure of psychological distress and incident cardiovascular events. Methods and Results In a prospective cohort study, we assessed 662 individuals (28% women; 30% blacks) with stable coronary artery disease. We used a composite score of psychological distress derived through summation of Z-transformed psychological distress symptom scales (depression, posttraumatic stress, anxiety, anger, hostility, and perceived stress) as a predictor of an adjudicated composite end point of adverse events (cardiovascular death, myocardial infarction, stroke, heart failure, or unstable angina). During a mean follow-up of 2.8 years, 120 (18%) subjects developed CVD events. In the overall population, there was no association between the psychological distress measure and CVD events, but there was a sex-based interaction ( P=0.004). In women, higher psychological distress was associated with a higher incidence of CVD events; each SD increase in the composite score of psychological distress was associated with 1.44 times adjusted hazard of CVD events (95% CI, 1.09-1.92). No such association was found in men. Conclusions Among patients with coronary artery disease, higher psychological distress is associated with future cardiovascular events in women only.

Indexed as

AgedCardiovascular DiseasesCoronary Artery DiseaseEmotionsFemaleGeorgiaHumansIncidenceMaleMental HealthMiddle AgedPrognosisProspective StudiesRisk FactorsSex FactorsStress, Psychologicalcardiovascular diseasedepressionlatent class analysispsychological stresssex differenceswomen

Identifiers

PMID31055991
PMCPMC6512132
OpenAlexW2944645904

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.