Evidence map›Paper›PMID 31055782›Full record

ArticleWorld journal of pediatrics : WJP2019

Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors.

Paola Muggeo, Vito Michele Rosario Muggeo, Paola Giordano, Maurizio Delvecchio, Maria Altomare, Chiara Novielli, Marco Matteo Ciccone, Gabriele D'Amato, Maria Felicia Faienza, Nicola Santoro

Abstract read
PubMed Publisher
In one paragraph

Article in World journal of pediatrics : WJP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Paola MuggeoDepartment of Pediatric Oncology and Hematology, University Hospital of Policlinico, Piazza G. Cesare 11, 70124, Bari, Italy. paola.muggeo@tiscali.it.ORCID http://orcid.org/0000-0001-8813-3200
Vito Michele Rosario MuggeoDepartment of Economical, Business and Statistical Sciences, University of Palermo, Palermo, Italy.
Paola GiordanoDepartment of Biomedicine and Human Oncology, Pediatric Section, University "A. Moro", Bari, Italy.
Maurizio DelvecchioPediatric and Neonatology Unit, Mother and Children Health Care Department, "Madonna delle Grazie" Hospital, ASL Matera, Matera, Italy.
Maria AltomareDepartment of Biomedicine and Human Oncology, Pediatric Section, University "A. Moro", Bari, Italy.
Chiara NovielliDepartment of Pediatric Oncology and Hematology, University Hospital of Policlinico, Piazza G. Cesare 11, 70124, Bari, Italy.
Marco Matteo CicconeCardiovascular Diseases Section, Department of Emergency and Organ Transplantation, University "A. Moro", Bari, Italy.
Gabriele D'AmatoNeonatal Intensive Care Unit, Di Venere Hospital, Bari, Italy.
Maria Felicia FaienzaDepartment of Biomedicine and Human Oncology, Pediatric Section, University "A. Moro", Bari, Italy.
Nicola SantoroDepartment of Pediatric Oncology and Hematology, University Hospital of Policlinico, Piazza G. Cesare 11, 70124, Bari, Italy.
Ospedale Pediatrico Giovanni XXIII · ITAzienda Universitaria Ospedaliera Consorziale - Policlinico Bari · ITOspedale Madonna Delle Grazie · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D (25-OHD) has a role in bone health after treatment for cancer. 25-OHD deficiency has been associated with risk factors for cardiovascular disease, but no data focusing on this topic in childhood cancer survivors have been published. We investigated the 25-OHD status in children treated for acute lymphoblastic leukemia (ALL), and evaluated its influence on vascular function.

methods25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy controls. Patients were grouped according to 25-OHD level (< 20 ng/m or ≥ 20 ng/ml). Auxological parameters, biochemical and hemostatic markers of endothelial function (AD, HMW-AD, ET-1, vWFAg, TAT, D-dimers, Fbg, and hs-CRP), ultrasound markers of vascular endothelial function (flow-mediated dilatation, FMD, common carotid intima-media thickness, C-IMT, and antero-posterior diameter of infra-renal abdominal aorta, APAO) were evaluated in the patients.

resultsCases showed higher prevalence of 25-OHD deficiency than controls (p = 0.002). In univariate analysis via mean comparisons, 25-OHD deficient (< 20 ng/ml) patients showed higher C-IMT values compared to the 25-OHD non-deficient (≥ 20 ng/ml) group (P = 0.023). Significant differences were also found for ET-1 (P = 0.035) and AD-HMW (P = 0.015). In the multiple regression models controlling for some confounders, 25-OHD still was associated with C-IMT (P = 0.0163), ET-1 (P = 0.0077), and AD-HMW (P = 0.0008).

conclusionsChildhood ALL survivors show higher prevalence of 25-OHD deficiency as compared to controls. The 25-OHD levels appear to be linked to indicators of endothelial and vascular dysfunction. Careful monitoring of 25-OHD balance may help to prevent cardiovascular diseases in childhood ALL survivors, characterized by high cardiovascular risk.

Indexed as

SurvivorsAdolescentBiomarkersChildChild, PreschoolEndothelium, VascularFemaleHumansMalePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsVitamin D DeficiencyYoung AdultBiomarkersAcute lymphoblastic leukemiaCardiovascular diseaseC-IMTVascular ultrasound studiesVitamin D

Identifiers

PMID31055782
OpenAlexW2942546357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.