SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019
Do 8- to 18-year-old children/adolescents with chronic physical health conditions have worse health-related quality of life than their healthy peers? a meta-analysis of studies using the KIDSCREEN questionnaires.
Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Children and young people at the intersection of chronic illness and migration: a scoping review.BMC global and public health · 2025Pooled it
- Non-disease specific patient-reported outcome measures of health-related quality of life in juvenile idiopathic arthritis: a systematic review of current research and practice.Rheumatology international · 2022Pooled it
- Health-related quality of life and self-reported health status in adolescents with chronic health conditions before transfer of care to adult health care: an international cohort study.BMC pediatrics · 2024Trial
- Health-related quality of life of children with first onset steroid-sensitive nephrotic syndrome.European journal of pediatrics · 2023Trial
- Health-related quality of life in children with Robin sequence following Tübingen palatal plate treatment in infancy.Archives of disease in childhood · 2026Article
- Correlates of social participation of children with special healthcare needs: baseline of the PART-CHILD study.BMC pediatrics · 2026Article
- Transitional Life Events in Friedreich Ataxia: Differential Age at Onset Perspectives.Cerebellum (London, England) · 2026Article
- Trajectories of health-related quality of life in youth with chronic physical illness and their siblings.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Delivering Health Education to Children With Chronic Conditions: A Scoping Review and Evidence and Gap Map.Child: care, health and development · 2026Article
- Disease control, psychiatric comorbidity, health-related quality of life, and experiences of care during transition to adult healthcare: a single-center prospective study.European journal of pediatrics · 2026Observational
- Paediatric Patients With Multiple Referrals and Complex Health Complaints Experienced Notable Functional Impairment.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- The health-related quality of life in children with IgA vasculitis.Frontiers in pediatrics · 2025Article
- Health-related quality of life of children with X-linked hypophosphatemia in Germany.Pediatric nephrology (Berlin, Germany) · 2024Observational
- Reference Values for the German Version of the Quality of Life after Brain Injury in Children and Adolescents (QOLIBRI-KID/ADO) from a General Population Sample.Journal of personalized medicine · 2024Article
- Diagnostic intervention improved health-related quality of life among teenagers with food allergy.PloS one · 2024Article
- Mental Health and Health-Related Quality of Life in Austrian Adolescents with Chronic Physical Health Conditions: Results from the MHAT Study.Journal of clinical medicine · 2023Article
- Fathers' Experiences of Caring for a Child with a Chronic Illness: A Systematic Review.Children (Basel, Switzerland) · 2023Review
- Use of KIDSCREEN health-related quality of life instruments in the general population of children and adolescents: a scoping review.Health and quality of life outcomes · 2023Article
- Health-Related Quality of Life in Children and Adolescents with Overweight, Obesity, and Severe Obesity: A Cross-Sectional Study.Obesity facts · 2023Article
- [Fatigue, quality of life, and use of healthcare resources in children with complex chronic diseases].Anales del sistema sanitario de Navarra · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeThis meta-analytic review aimed to estimate the magnitude of health-related quality of life (HrQoL) impairments, as assessed by the KIDSCREEN questionnaires, both self- and parent-reported, in 8- to 18-years-old children/adolescents with chronic health conditions.
methodsTo identify studies using the KIDSCREEN questionnaires, three electronic databases (PubMed, PsycINFO, EBSCOhost Psychology & Behavioral Sciences) were searched. The final search (February 14-15, 2018) revealed 528 non-duplicated articles, of which 23 papers (21 studies) directly compared the HrQoL of pediatric patients to community/healthy controls and were included in the meta-analysis. Pooled mean differences (MD) with 95% CIs were estimated using the inverse-variance random-effects method.
resultsOf the 21 studies, 16 used self-reports, one used parent-reports and four adopted a multi-informant approach. Self-reported data were retrieved from 20 studies (4852 cases/28,578 controls), and parent-reported data were retrieved from four studies (511 cases/433 controls). Pediatric patients presented significant HrQoL impairments in the domains of physical well-being (MD = - 4.84, 95% CI - 6.44/- 3.24 for self-reports; MD = - 6.86, 95% CI - 10.42/- 3.29 for parent-reports) and peers and social support (MD = - 1.29, 95% CI - 2.25/- 0.34 for self-reports; MD = - 3.90, 95% CI - 5.28/- 2.52 for parent-reports), compared to community/healthy peers. Between-studies heterogeneity was explained by diagnostic categories, instrument version and informants.
conclusionsThe identification of significant HrQoL impairments among pediatric patients, specifically in the physical and social domains, highlights the importance of routine psychosocial assessment and intervention in primary pediatric healthcare services. Specific recommendations include the use of profile measures, both self- and parent-reports, and the prioritization of oncology, endocrinology and neurology services.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.