Evidence map›Paper›PMID 31055727›Full record

ArticleSleep & breathing = Schlaf & Atmung2020

Gender-specific change in leptin concentrations during long-term CPAP therapy.

Miia Aro, Ulla Anttalainen, Samu Kurki, Kerttu Irjala, Olli Polo, Tarja Saaresranta

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Miia AroDivision of Medicine, Department of Pulmonary Diseases, Turku University Hospital, PO Box 52, FI-20520, Turku, Finland. mmisot@utu.fi.ORCID http://orcid.org/0000-0002-3072-9164
Ulla AnttalainenDivision of Medicine, Department of Pulmonary Diseases, Turku University Hospital, PO Box 52, FI-20520, Turku, Finland.
Samu KurkiAuria Biobank, University of Turku and Turku University Hospital, Turku, Finland.
Kerttu IrjalaDepartment of Clinical Chemistry, University of Turku, Turku, Finland.
Olli PoloDepartment of Pulmonary Diseases, Tampere University Hospital, Tampere, Finland.
Tarja SaaresrantaDivision of Medicine, Department of Pulmonary Diseases, Turku University Hospital, PO Box 52, FI-20520, Turku, Finland.
University of Turku · FITampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNasal continuous positive airway pressure (CPAP) alleviates sleepiness in patients with obstructive sleep apnoea syndrome (OSAS), but part of OSAS patients keep gaining weight. Leptin and insulin-like growth factor-1 (IGF-1) interact with energy balance, and CPAP therapy has been suggested to influence these endocrine factors. We hypothesised that leptin would decrease during long-term CPAP therapy, and weight gain would associate with OSAS severity, lower CPAP adherence, lower IGF-1, and leptin concentrations.

methodsConsecutive patients (n = 223) referred to sleep study with suspected OSAS were enrolled. Patients underwent cardiorespiratory polygraphy at baseline. Questionnaires were completed, and blood samples were drawn both at baseline and after 3 years. A total of 149 (67%; M 65, F 84) patients completed the follow-up. Plasma samples were available from 114 patients, 109 of which with CPAP adherence data (49 CPAP users, 60 non-users).

resultsAt baseline, the CPAP users were more obese and had more severe OSAS than the non-users. Leptin concentrations did not differ. After follow-up, leptin concentrations were higher in CPAP users (30.2 ng/ml vs. 16.8 ng/ml; p = 0.001). In regression analysis, increase in leptin concentrations was independent of age, baseline body mass index (BMI), or the change in BMI. Leptin concentrations increased among females (- 8.9 vs. 12.7 ng/ml; p < 0.001); whereas in men, CPAP did not have an effect, if not opposed the natural decrease in leptin observed in men not using CPAP. Change in IGF-1 levels did not differ.

conclusionsOur results suggest increase in leptin concentrations during long-term CPAP therapy among females.

Indexed as

Continuous Positive Airway PressureLong-Term CareAdultAgedFemaleHumansInsulin-Like Growth Factor ILeptinMaleMiddle AgedPatient CompliancePolysomnographySex FactorsSleep Apnea, ObstructiveInsulin-Like Growth Factor ILeptinGender-specificLeptinLong-term CPAP therapySleep apnoea

Identifiers

PMID31055727
PMCPMC7128000
OpenAlexW2943834508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.