Evidence map›Paper›PMID 31055642›Full record

ReviewRheumatology international2019

Polymyositis with mitochondrial pathology or atypical form of sporadic inclusion body myositis: case series and review of the literature.

George K Papadimas, Charalampos Kokkinis, Sophia Xirou, Margarita Chrysanthou, Evangelia Kararizou, Constantinos Papadopoulos

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Rheumatology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

George K Papadimas1st Department of Neurology, Medical School, Eginition Hospital, National and Kapodistrian University of Athens, 74, Vas. Sophias Ave, 11528, Athens, Greece. gkpapad@yahoo.gr.ORCID https://orcid.org/0000-0003-0163-4091
Charalampos KokkinisDepartment of Medical Genetics, Medical School, St. Sofia's Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-4430-4255
Sophia Xirou1st Department of Neurology, Medical School, Eginition Hospital, National and Kapodistrian University of Athens, 74, Vas. Sophias Ave, 11528, Athens, Greece.ORCID https://orcid.org/0000-0001-8222-091X
Margarita Chrysanthou1st Department of Neurology, Medical School, Eginition Hospital, National and Kapodistrian University of Athens, 74, Vas. Sophias Ave, 11528, Athens, Greece.ORCID https://orcid.org/0000-0001-5342-4585
Evangelia Kararizou1st Department of Neurology, Medical School, Eginition Hospital, National and Kapodistrian University of Athens, 74, Vas. Sophias Ave, 11528, Athens, Greece.ORCID https://orcid.org/0000-0003-3616-4552
Constantinos Papadopoulos1st Department of Neurology, Medical School, Eginition Hospital, National and Kapodistrian University of Athens, 74, Vas. Sophias Ave, 11528, Athens, Greece.ORCID https://orcid.org/0000-0001-7633-5032
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymyositis with mitochondrial pathology (PM-Mito) is a rare form of idiopathic inflammatory myopathy with no definite diagnostic criteria and similarities to both PM and sporadic inclusion body myositis (s-IBM). The aim of this study is to address the dilemma of whether PM-Mito is a subtype of inflammatory myopathy or represents a disease falling into the spectrum of s-IBM. Herein, we report four female patients diagnosed with PM-Mito, highlighting their rather atypical clinical and histopathological characteristics that seem to indicate a diagnosis away from s-IBM. Muscle weakness was rather proximal and symmetrical and lacked the selective pattern observed in s-IBM. Patients had large-scale deletions in mtDNA, reflecting the mitochondrial component in the pathology of the disease. Conclusively, our study adds to the limited data in the literature on whether PM-Mito is a distinct form of myositis or represents a prodromal stage of s-IBM. Although the latter seems to be supported by a substantial body of evidence, there are, however, important differences, such as the different patterns of muscle weakness, and the good response to treatment observed in some patients. Larger-scale studies are certainly needed to clarify pathogenesis and clinical characteristics of PM-Mito patients, especially in therapeutic and prognostic terms.

Indexed as

AdultAgedBiopsyDiagnosis, DifferentialDNA, MitochondrialFemaleGene DeletionGlucocorticoidsHumansImmunosuppressive AgentsMiddle AgedMitochondria, MuscleMuscle, SkeletalMuscle WeaknessMyositis, Inclusion BodyPolymyositisDNA, MitochondrialGlucocorticoidsImmunosuppressive AgentsInclusion body myositisMitochondriamtDNAPolymyositis

Identifiers

PMID31055642
OpenAlexW2943486102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.