Evidence map›Paper›PMID 31055200›Full record

ArticleNeoplasia (New York, N.Y.)2019

Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome.

Xiaofan Lu, Liyun Jiang, Liya Zhang, Yue Zhu, Wenjun Hu, Jiashuo Wang, Xinjia Ruan, Zhengbao Xu, Xiaowei Meng, Jun Gao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Neoplasia (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 250 citations in OpenAlex.

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  10. Genes & diseases · 2025
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Xiaofan LuResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Liyun JiangResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Liya ZhangResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Yue ZhuResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Wenjun HuResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Jiashuo WangResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Xinjia RuanResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Zhengbao XuResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Xiaowei MengResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Jun GaoResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China.
Xiaoping SuDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: xsu1@mdanderson.org.
Fangrong YanResearch Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, PR, China. Electronic address: f.r.yan@163.com.
China Pharmaceutical University · CNThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Substantial heterogeneity exists within cervical cancer that is generally infected by human papillomavirus (HPV). However, the most common histological subtype of cervical cancer, cervical squamous cell carcinoma (CSCC), is poorly characterized regarding the association between its heterogeneity and HPV oncoprotein expression. We filtered out 138 CSCC samples with infection of HPV16 only as the first step; then we compressed HPV16 E6/E7 expression as HPV

Indexed as

AdultCarcinoma, Squamous CellClass I Phosphatidylinositol 3-KinasesDNA MethylationF-Box-WD Repeat-Containing Protein 7FemaleGene Expression Regulation, NeoplasticHuman papillomavirus 16HumansKaplan-Meier EstimateKeratin-1Middle AgedMucin-4Oncogene Proteins, ViralPapillomavirus E7 ProteinsPapillomavirus InfectionsClass I Phosphatidylinositol 3-KinasesE6 protein, Human papillomavirus type 16F-Box-WD Repeat-Containing Protein 7FBXW7 protein, humanKeratin-1KRT1 protein, humanMUC4 protein, humanMucin-4oncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsPIK3CA protein, humanRepressor Proteins

Identifiers

PMID31055200
PMCPMC6658934
OpenAlexW2943793962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.