SynthesisNeurobiology of aging2019
Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies.
Synthesis in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Psilocybin in Older Adults: Therapeutic Opportunities in Inflammation-Driven Disorders of Aging-From Depression to Neurodegeneration.International journal of molecular sciences · 2026Review
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Partial Serotonin Transporter Deficiency Modulates Plasma Metabolome, Arginine-Nitric Oxide Pathway and Emotional Behavior in Mice Exposed to Western Diet.Metabolites · 2026Article
- Depression and risk of gastro-oesophageal reflux disease (GERD): results from the UK Biobank study.BMC gastroenterology · 2026Article
- Article
- Molecular Aspects of Geriatric Pharmacotherapy.Cells · 2025Review
- Multimodal neuroimaging insights into the neurobiology of healthy aging across the lifespan.European journal of nuclear medicine and molecular imaging · 2025Article
- Cigarette smoking is associated with levels of the serotonin transporter in the brain: a [11C]DASB PET Study.The international journal of neuropsychopharmacology · 2025Article
- Enhanced CYP2C19-mediated drug-drug interaction risk with escitalopram in geriatric populations.Frontiers in pharmacology · 2025Article
- Editorial: Suicide in geriatric populations.Frontiers in psychiatry · 2025Article
- Multimodal brain age prediction using machine learning: combining structural MRI and 5-HT2AR PET-derived features.GeroScience · 2024Article
- Effects of Psychedelics in Older Adults: A Prospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Observational
- Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults.GeroScience · 2024Article
- Addressing Combative Behaviour in Spanish Bulls by Measuring Hormonal Indicators.Veterinary sciences · 2024Article
- Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies.Ageing research reviews · 2024Review
- Knowledge gaps in psychedelic medicalisation: Clinical studies and regulatory aspects.Neuroscience applied · 2024Review
- Poorer aging trajectories are associated with elevated serotonin synthesis capacity.Molecular psychiatry · 2023Article
- Regional serotonin terminal density in aging human brain: A [Aging brain · 2023Article
- Mapping neurotransmitter systems to the structural and functional organization of the human neocortex.Nature neuroscience · 2022Article
- In vivo correlation of serotonin transporter and 1B receptor availability in the human brain: a PET study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in older age. Here, we conducted a quantitative synthesis and comparison of the effects of age on 5-HT receptors and transporters from cross-sectional positron emission tomography and single-photon emission computed tomography imaging studies. Random-effects meta-analyses of 31 studies including 1087 healthy adults yielded large negative effects of age in 5-HT-2A receptors (largest in global cortex), moderate negative effects of age in 5-HT transporters (largest in thalamus), and small negative effects of age in 5-HT-1A receptors (largest in parietal cortex). Presynaptic 5-HT-1A autoreceptors in raphe/midbrain, however, were preserved across adulthood. Adult age differences were significantly larger in 5-HT-2A receptors compared with 5-HT-1A receptors. A meta-regression showed that 5-HT target, radionuclide, and publication year significantly moderated the age effects. The findings overall identify reduced serotonergic signal transmission in healthy aging. The evidence for the relative preservation of 5-HT-1A compared with 5-HT-2A receptors may partially explain psychological age differences, such as why older adults use more emotion-focused rather than problem-focused coping strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.