Evidence map›Paper›PMID 31055004›Full record

ReviewExperimental neurology2019

Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI.

Naomi S Sta Maria, Saman Sargolzaei, Mayumi L Prins, Emily L Dennis, Robert F Asarnow, David A Hovda, Neil G Harris, Christopher C Giza

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07538440 (Prediction Model in Paediatric Moderate to Severe TBI), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07538440 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Prediction Model in Paediatric Moderate to Severe TBI

Typeobservational_patient_registrySponsorCambridge University Hospitals NHS Foundation TrustRan2025 to 2026Enrolled2,000ConditionsTraumatic Brain Injury (TBI)
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naomi S Sta MariaDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, ZNI115, Los Angeles, CA 90033, United States of America. Electronic address: nstamari@usc.edu.
Saman SargolzaeiUCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America. Electronic address: ssargolzaei@mednet.ucla.edu.
Mayumi L PrinsUCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Steve Tisch BrainSPORT Program, University of California at Los Angeles, Los Angeles, CA, United States of America. Electronic address: mprins@mednet.ucla.edu.
Emily L DennisBrigham and Women's Hospital/Harvard University and Department of Psychology, Stanford University, 1249 Boylston Street, Boston, MA 02215, United States of America. Electronic address: edennis@bwh.harvard.edu.
Robert F AsarnowDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Box 951759, 760 Westwood Plaza, 48-240C Semel Institute, Los Angeles, CA 90095-1759, United States of America. Electronic address: rasarnow@mednet.ucla.edu.
David A HovdaUCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Department of Medical and Molecular Pharmacology, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562 & Semel 18-228A, Los Angeles, CA 90095-6901, United States of America. Electronic address: dhovda@mednet.ucla.edu.
Neil G HarrisUCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Intellectual Development and Disabilities Research Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States of America. Electronic address: ngharris@ucla.edu.
Christopher C GizaUCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Steve Tisch BrainSPORT Program, University of California at Los Angeles, Los Angeles, CA, United States of America; Division of Pediatric Neurology, Mattel Children's Hospital - UCLA, Los Angeles, CA, United States of America. Electronic address: cgiza@mednet.ucla.edu.

Funding

UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
New Electrographic Biomarkers of EpileptogenesisR01NS065877 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAGIN, ANATOL · 2010 to 2018
$4.0M
Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
A mechanism for stunted map plasticity after TBIR01NS091222 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRIS, NEIL · 2015 to 2019
$1.7M
Predictive accuracy of acute astroglial compromise biomarkers after traumatic brain injuryUG3NS106945 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRIS, NEIL, WANNER, INA BEATE · 2018 to 2020
$882k
New Biomarkers of EpileptogenesisR56NS065877 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAGIN, ANATOL · 2019 to 2019
$540k
Advanced Morphological Analysis of Cerebral Blood Flow for Acute Concussion DiagnosisR43NS092209 · NINDS · NEURAL ANALYTICS, INC. · PI HAMILTON, ROBERT · 2015 to 2015
$150k
NICHD NIH HHS U54 HD087101NINDS NIH HHS R01 NS027544NINDS NIH HHS R01 NS065877NINDS NIH HHS R01 NS091222NINDS NIH HHS R43 NS092209NINDS NIH HHS R56 NS065877NINDS NIH HHS UG3 NS106945
6 · The paper itself

Abstract

Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.

Indexed as

Brain Injuries, TraumaticChildChild, PreschoolHumansInfantInfant, NewbornNerve RegenerationNeuronal PlasticityRecovery of FunctionDevelopmentPediatric TBIPlasticityTraumatic brain injury

Identifiers

PMID31055004
PMCPMC7371366

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.